Human Endogenous Retroviruses and Type 1 Diabetes.

Levet, Sandrine; Charvet, B.; Bertin, Antoine; Deschaumes, Arthur; Perron, H.; Hober, Didier

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1007/s11892-019-1256-9

PMID :

31754894

URL permanente :

http://hdl.handle.net/20.500.12210/102854

Titre :

Human Endogenous Retroviruses and Type 1 Diabetes.

Auteur(s) :

Levet, Sandrine [Auteur]
Charvet, B. [Auteur]
Bertin, Antoine [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Deschaumes, Arthur [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Perron, H. [Auteur]
Hober, Didier [Auteur]

Laboratoire de virologie - ULR 3610

Titre de la revue :

Current Diabetes Reports

Nom court de la revue :

Curr. Diab. Rep.

Numéro :

Pagination :

141

Date de publication :

2019-11-23

ISSN :

1539-0829

Mot(s)-clé(s) en anglais :

Endogenous retrovirus
Type 1 diabetes
HERV
Enterovirus
Coxsackievirus B4

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Purpose of the Review The aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1 diabetes (T1D) onset and progression. Recent Findings The envelope ...
Lire la suite >Purpose of the Review The aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1 diabetes (T1D) onset and progression. Recent Findings The envelope protein of HERV-W family, named HERV-W-Env, was detected in pancreata from T1D patients and was shown to display pro-inflammatory properties and direct toxicity toward pancreatic beta cells. Summary The etiopathogenesis of T1D remains elusive, even if conventional environmental viral infections have been recurrently involved. Nonetheless, a new category of pathogens may provide the missing link between genetic susceptibility and environmental factors long thought to contribute to T1D onset. A number of studies have now shown that HERV sequences, which are normally inactivated or repressed in the human genome, could be activated by environmental viruses. Thus, if similarly activated by viruses associated with T1D, disregarded HERV genes may underlie T1D genetic susceptibility. Moreover, once expressed, HERV elements may display broad pathogenic properties, which identify them as potential new therapeutic targets.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

Laboratoire de virologie - ULR 3610

Date de dépôt :

2024-01-17T22:25:50Z
2024-02-08T14:41:55Z

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s11892-019-1256-9.pdf
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Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/102854*	2024-02-08T14:36:37Z
1	20.500.12210/102854.1	2024-01-17T22:25:50Z

Human Endogenous Retroviruses and Type 1 Diabetes.

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Human Endogenous Retroviruses and Type 1 Diabetes.

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