Titre :

Life expectancy and likelihood of surgery in multiple endocrine neoplasia type 1: AFCE and GTE cohort study.

Auteur(s) :

Gaujoux, Sébastien [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Martin, Guillaume L [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Mirallié, Eric [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Regenet, Nicolas [Auteur]
Le Bras, Maëlle [Auteur]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Carnaille, Bruno [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Cardot-Bauters, Catherine [Auteur]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]
Groussin, Lionel [Auteur]
Service d'Endocrinologie [CHU Cochin]
Faron, Matthieu [Auteur]
Institut Gustave Roussy [IGR]
Chanson, Philippe [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Physiologie et physiopathologie endocriniennes [PHYSENDO]
Najah, Haythem [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Tabarin, A. [Auteur]
Sauvanet, A. [Auteur]
Ruszniewski, P. [Auteur]
Lifante, J. C. [Auteur]
Université de Lyon
Hospices Civils de Lyon [HCL]
Walter, T. [Auteur]
Carrère, N. [Auteur]
Caron, P. [Auteur]
Deguelte, S. [Auteur]
Delemer, B. [Auteur]
Binquet, C. [Auteur]
CHU Dijon
Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques [CIC-EC]
Jannot, Anne Sophie [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Département d'Informatique et Santé Publique [CHU HEGP] [HEGP - Informatique]
Goudet, Pierre [Auteur]
Epidémiologie et recherche clinique en oncologie digestive (CTM UMR 1231) [EPICAD]

Titre de la revue :

British Journal of Surgery

Nom court de la revue :

Br J Surg

Date de publication :

2022-07-19

ISSN :

1365-2168

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background The overall natural history, risk of death and surgical burden of patients with multiple endocrine neoplasia type 1 (MEN1) is not well known. Methods Patients with MEN1 from a nationwide cohort were included. ...
Lire la suite >Background The overall natural history, risk of death and surgical burden of patients with multiple endocrine neoplasia type 1 (MEN1) is not well known. Methods Patients with MEN1 from a nationwide cohort were included. The survival of patients with MEN1 was compared with that of the general population using simulated controls. The cumulative probabilities of MEN1-specific operations and postoperative mortality were assessed, and surgical sequences were analysed using sunburst charts and Venn diagrams. Results A total of 1386 patients with MEN1 were included. Life expectancy was significantly reduced in patients with MEN1 compared with simulated controls from the general population, with a lifetime difference of 15 years. Mutations affecting the JunD interaction domain had a significant negative impact on survival. Survival for patients with MEN1 compared with the general population improved over time. The probability of experiencing at least one specific MEN1 operation was above 95 per cent after 75 years, and most patients had surgery at least twice during their lifetime. Time to a 50 per cent risk of MEN1 surgery was 30.5 years for patients born after 1960, compared with 47.9 years for those born before 1960. Sex and mutations affecting the JunD interacting domain had no impact on time to first surgery. There was considerable heterogeneity in surgical sequences, with no specific clinical pathway. Conclusion Life expectancy was significantly lower among patients with MEN1 compared with the general population, and further decreased in patients with mutations affecting the JunD interacting domain. Almost all patients underwent at least one MEN1-specific operation during their lifetime, but there was no standardized sequence of surgery.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Date de dépôt :

2024-01-19T22:35:32Z
2024-06-19T14:13:52Z