Titre :

Pancreatoduodenectomy for Neuroendocrine Tumors in Patients with Multiple Endocrine Neoplasia Type 1: An AFCE (Association Francophone de Chirurgie Endocrinienne) and GTE (Groupe d'étude des Tumeurs Endocrines) Study.

Auteur(s) :

Santucci, Nicolas [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]
Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon)
Gaujoux, Sébastien [Auteur]
Hôpital Cochin [AP-HP]
Binquet, Christine [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]
Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques [CIC-EC]
Reichling, Cynthia [Auteur]
Département de chirurgie thoracique et digestive [CHU de Dijon]
Lifante, Jean-Christophe [Auteur]
Health Service and Performance Research [HESPER]
Université Claude Bernard Lyon 1 [UCBL]
Carnaille, Bruno [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Mirallié, Eric [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Facy, Olivier [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Mathonnet, Muriel [Auteur]
Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges]
Goudet, Pierre [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]

Titre de la revue :

World Journal of Surgery

Nom court de la revue :

World J Surg

Numéro :

45

Pagination :

1794-1802

Date de publication :

2021-03-01

ISSN :

1432-2323

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Aim To assess postoperative complications and control of hormone secretions following pancreatoduodenectomy (PD) performed on multiple endocrine neoplasia type 1 (MEN1) patients with duodenopancreatic neuroendocrine tumors ...
Lire la suite >Aim To assess postoperative complications and control of hormone secretions following pancreatoduodenectomy (PD) performed on multiple endocrine neoplasia type 1 (MEN1) patients with duodenopancreatic neuroendocrine tumors (DP-NETs). Background The use of PD to treat MEN1 remains controversial, and evaluating the right place of PD in MEN1 disease makes sense. Methods Thirty-one MEN1 patients from the Groupe d’étude des Tumeurs Endocrines MEN1 cohort who underwent PD for DP-NETs between 1971 and 2013 were included. Early and late postoperative complications, secretory control and overall survival were analyzed. Results Indication for surgery was: Zollinger–Ellison syndrome (n = 18; 58%), nonfunctioning tumor (n = 9; 29%), insulinoma (n = 2; 7%), VIPoma (n = 1; 3%) and glucagonoma (n = 1; 3%). Mean follow-up was 141 months (range 0–433). Pancreatic fistulas occurred in 5 patients (16.1%), distant metastases in 6 (mean onset of 43 months; range 13–110 months), postoperative diabetes mellitus in 7 (22%), and pancreatic exocrine insufficiency in 6 (19%). Five-year overall survival was 93.3% [CI 75.8–98.3] and ten-year overall survival was 89.1% [CI 69.6–96.4]. After a mean follow-up of 151 months (range 0–433), the biochemical cure rate for MEN-1 related gastrinomas was 61%. Conclusion In MEN1 patients, pancreatoduodenectomy can be used to control hormone secretions (gastrin, glucagon, VIP) and to remove large NETs. PD was found to control gastrin secretions in about 60% of cases.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Date de dépôt :

2024-01-19T23:11:30Z
2024-10-16T09:26:02Z