Title :

Early switch from tacrolimus to everolimus after liver transplantation: outcomes at two years

Author(s) :

Saliba, Faouzi [Auteur]
Hôpital Paul Brousse
Duvoux, Christophe [Auteur]
Hôpital Henri Mondor
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dumortier, Jerome [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Calmus, Yvon [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Gugenheim, Jean [Auteur]
Hôpital Archet 2 [Nice] [CHU]
Kamar, Nassim [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Salame, Ephrem [Auteur]
CHU Trousseau [Tours]
Neau-Cransac, Martine [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Vanlemmens, Claire [Auteur]
Durand, Francois [Auteur]
Hôpital Beaujon [AP-HP]
Pageaux, Georges-Philippe [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Leroy, Vincent [Auteur]
Hôpital Michallon
Hardwigsen, Jean [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Gharbi, Hakam [Auteur]
Masson, Cecile [Auteur]
Tindel, Malka [Auteur]
Conti, Filomena [Auteur]
CHU Pitié-Salpêtrière [AP-HP]

Journal title :

Liver Transplantation

Abbreviated title :

Liver Transpl.

Volume number :

25

Pages :

1822-1832

Publication date :

2019-12

ISSN :

1527-6473

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The observational CERTITUDE study follows liver transplant patients who completed the SIMCER trial. SIMCER randomized patients at month 1 after transplant to everolimus (EVR) with stepwise tacrolimus (TAC) withdrawal or ...
Show more >The observational CERTITUDE study follows liver transplant patients who completed the SIMCER trial. SIMCER randomized patients at month 1 after transplant to everolimus (EVR) with stepwise tacrolimus (TAC) withdrawal or to standard TAC, both with basiliximab induction and mycophenolic acid ± steroids. After completing SIMCER at 6 months after transplant, 65 EVR-treated patients and 78 TAC-treated patients entered CERTITUDE. At month 24 after transplant, 34/65 (52.3%) EVR-treated patients remained calcineurin inhibitor (CNI) free. Mean estimated glomerular filtration rate (eGFR) was significantly higher with EVR versus TAC during months 3-12. At month 24, eGFR values were 83.6 versus 75.3 mL/minute/1.73 m22Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:14Z
2024-04-04T13:18:36Z