Title :

Risk factors for early graft failure and�death after kidney transplantation in�recipients older than 70 years

Author(s) :

Lemoine, Mathilde [Auteur]
Titeca-Beauport, Dimitri [Auteur]
Lobbedez, Thierry [Auteur]
Choukroun, Gabriel [Auteur]
Hurault De Ligny, Bruno [Auteur]
Hazzan, Marc [Auteur]
Guerrot, Dominique [Auteur]
Bertrand, Dominique [Auteur]

Journal title :

Kidney International Reports

Abbreviated title :

Kidney Int Rep

Volume number :

4

Pages :

656-666

Publication date :

2019-05-01

ISSN :

2468-0249

English keyword(s) :

elderly
cardiovascular disease
graft failure
infectious disease
kidney transplantation
patient death

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Although kidney transplantation carries a survival benefit compared with dialysis, mortality, especially the first year after transplantation, is high in recipients older than 70. The aim of this study was to ...
Show more >BACKGROUND: Although kidney transplantation carries a survival benefit compared with dialysis, mortality, especially the first year after transplantation, is high in recipients older than 70. The aim of this study was to evaluate early death and graft failure, and to determine the risk factors associated with these events in this specific population. METHODS: All patients older than 70 years who received a kidney transplant between January 2000 and December 2014 in the North-West of France were included (n RESULTS: The mean recipient age was 73.3 ± 2.5 years. Death-censored graft survival at 1, 3, and 5 years were 82.6%, 78.7%, and 75.4%, respectively. Patient survival at 1, 3, and 5 years was 90.1%, 82.5%, and 68.1%, respectively. One year after transplantation, 17 patients (9.9%) were dead, mainly from infectious (58.5%) or cardiovascular disease (29.4%). According to the Cox multivariate analysis, the independent risk factors for death or graft failure during the first year were arrhythmia (odds ratio [OR] 2.26; 95% confidence interval [CI] 1.08-4.8), left-ventricular ejection fraction (LVEF) under 56% (OR 2.38; 95% CI 1.18-4.83), human leucocyte antigen (HLA) antibodies (OR 2.1; 95% CI 1.04-4.2), deceased donor from cardiovascular cause (OR 5.18; 95% CI 1.22-6.3), and acute rejection (OR 2.77; 95% CI 1.2-6.3). CONCLUSIONS: In kidney transplant recipients older than 70 years, cardiac evaluation and immunosuppression optimization seem to be crucial to improve short-term patient and graft survival.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:35Z