Conditioning-based outcomes after allogeneic ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Conditioning-based outcomes after allogeneic transplantation for myeloma following a prior autologous transplant (1991-2012) on behalf of ebmt cmwp
Auteur(s) :
Hayden, Patrick [Auteur]
Iacobelli, Simona [Auteur]
Perez-Simon, Jose Antonio [Auteur]
Van Biezen, Anja [Auteur]
Minnema, Monique [Auteur]
Niittyvuopio, Riitta [Auteur]
Schonland, Stefan [Auteur]
Meijer, Ellen [Auteur]
Blaise, Didier [Auteur]
Centre de Recherche en Cancérologie de Marseille [CRCM]
Milpied, Noel [Auteur]
Marquez-Malaver, Francisco J. [Auteur]
Veelken, Hendrik [Auteur]
Maertens, Johan [Auteur]
Michallet, Mauricette [Auteur]
Cammenga, Jorg [Auteur]
Nguyen, Stephanie [Auteur]
Niederwieser, Dietger [Auteur]
Hunault-Berger, Mathilde [Auteur]
Bourhis, Jean-Henri [Auteur]
Institut Gustave Roussy [IGR]
Passweg, Jakob [Auteur]
Bermudez, Arancha [Auteur]
Chalandon, Yves [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Garderet, Laurent [Auteur]
Kroger, Nicolaus [Auteur]
Iacobelli, Simona [Auteur]
Perez-Simon, Jose Antonio [Auteur]
Van Biezen, Anja [Auteur]
Minnema, Monique [Auteur]
Niittyvuopio, Riitta [Auteur]
Schonland, Stefan [Auteur]
Meijer, Ellen [Auteur]
Blaise, Didier [Auteur]
Centre de Recherche en Cancérologie de Marseille [CRCM]
Milpied, Noel [Auteur]
Marquez-Malaver, Francisco J. [Auteur]
Veelken, Hendrik [Auteur]
Maertens, Johan [Auteur]
Michallet, Mauricette [Auteur]
Cammenga, Jorg [Auteur]
Nguyen, Stephanie [Auteur]
Niederwieser, Dietger [Auteur]
Hunault-Berger, Mathilde [Auteur]
Bourhis, Jean-Henri [Auteur]
Institut Gustave Roussy [IGR]
Passweg, Jakob [Auteur]
Bermudez, Arancha [Auteur]
Chalandon, Yves [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Garderet, Laurent [Auteur]
Kroger, Nicolaus [Auteur]
Titre de la revue :
European Journal of Haematology
Nom court de la revue :
Eur. J. Haematol.
Numéro :
104
Pagination :
181-189
Date de publication :
2020-03
ISSN :
1600-0609
Mot(s)-clé(s) en anglais :
myeloma
EBMT
conditioning
CMWP
allogeneic transplantation
EBMT
conditioning
CMWP
allogeneic transplantation
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVE: The aim of this study was to compare the effect of the intensity of conditioning approaches used in allogeneic transplantation in myeloma-reduced intensity conditioning (RIC), non-myeloablative (NMA), myeloablative ...
Lire la suite >OBJECTIVE: The aim of this study was to compare the effect of the intensity of conditioning approaches used in allogeneic transplantation in myeloma-reduced intensity conditioning (RIC), non-myeloablative (NMA), myeloablative conditioning (MAC) or Auto-AlloHCT-on outcomes in patients who had had a prior autologous transplant. METHODS: A retrospective analysis of the EBMT database (1991-2012) was performed. RESULTS: A total of 344 patients aged between 40 and 60 years at the time of alloHCT were identified: 169 RIC, 69 NMA, 65 MAC and 41 Auto-Allo transplants. At a median follow-up of 54 months, the probabilities of overall survival (OS) at 5 years were 39% (95% CI 31%-47%), 45% (95% CI 32%-57%), 19% (95% CI 6%-32%) and 34% (95% CI 17%-51%), respectively. Status at allogeneic HCT other than CR or PR conferred a 70% higher risk of death and a 40% higher risk of relapse. OS was markedly lower in the MAC group (P = .004). MAC alloHCT was associated with a higher risk of death than RIC alloHCT until 2002 (HR = 4.1, P < .001) but not after 2002 (HR = 1.2, P = .276). CONCLUSIONS: From 1991 to 2002, MAC was associated with poorer OS. Between 2003 and 2012, there were no significant differences in outcomes based on these different approaches.Lire moins >
Lire la suite >OBJECTIVE: The aim of this study was to compare the effect of the intensity of conditioning approaches used in allogeneic transplantation in myeloma-reduced intensity conditioning (RIC), non-myeloablative (NMA), myeloablative conditioning (MAC) or Auto-AlloHCT-on outcomes in patients who had had a prior autologous transplant. METHODS: A retrospective analysis of the EBMT database (1991-2012) was performed. RESULTS: A total of 344 patients aged between 40 and 60 years at the time of alloHCT were identified: 169 RIC, 69 NMA, 65 MAC and 41 Auto-Allo transplants. At a median follow-up of 54 months, the probabilities of overall survival (OS) at 5 years were 39% (95% CI 31%-47%), 45% (95% CI 32%-57%), 19% (95% CI 6%-32%) and 34% (95% CI 17%-51%), respectively. Status at allogeneic HCT other than CR or PR conferred a 70% higher risk of death and a 40% higher risk of relapse. OS was markedly lower in the MAC group (P = .004). MAC alloHCT was associated with a higher risk of death than RIC alloHCT until 2002 (HR = 4.1, P < .001) but not after 2002 (HR = 1.2, P = .276). CONCLUSIONS: From 1991 to 2002, MAC was associated with poorer OS. Between 2003 and 2012, there were no significant differences in outcomes based on these different approaches.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Date de dépôt :
2024-01-30T10:28:10Z
2024-01-30T15:03:25Z
2024-01-30T15:03:25Z