Titre :

Epigenetics: linking early postnatal nutrition to obesity programming?

Auteur(s) :

Marousez, Lucie [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lesage, Jean [Auteur]
Eberle, Delphine [Auteur]
Environnement Périnatal et Santé - EA 4489

Titre de la revue :

Nutrients

Nom court de la revue :

Nutrients

Numéro :

11

Date de publication :

2019-12-05

ISSN :

2072-6643

Mot(s)-clé(s) en anglais :

breast milk
DNA methylation
early postnatal nutrition
developmental programming
epigenetics
obesity

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Despite constant research and public policy efforts, the obesity epidemic continues to be a major public health threat, and new approaches are urgently needed. It has been shown that nutrient imbalance in early life, from ...
Lire la suite >Despite constant research and public policy efforts, the obesity epidemic continues to be a major public health threat, and new approaches are urgently needed. It has been shown that nutrient imbalance in early life, from conception to infancy, influences later obesity risk, suggesting that obesity could result from "developmental programming". In this review, we evaluate the possibility that early postnatal nutrition programs obesity risk via epigenetic mechanisms, especially DNA methylation, focusing on four main topics: (1) the dynamics of epigenetic processes in key metabolic organs during the early postnatal period; (2) the epigenetic effects of alterations in early postnatal nutrition in animal models or breastfeeding in humans; (3) current limitations and remaining outstanding questions in the field of epigenetic programming; (4) candidate pathways by which early postnatal nutrition could epigenetically program adult body weight set point. A particular focus will be given to the potential roles of breast milk fatty acids, neonatal metabolic and hormonal milieu, and gut microbiota. Understanding the mechanisms by which early postnatal nutrition can promote lifelong metabolic modifications is essential to design adequate recommendations and interventions to "de-program" the obesity epidemic.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Date de dépôt :

2024-01-30T10:28:14Z