Title :

Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT.

Author(s) :

Gurnari, Carmelo [Auteur]
Cleveland Clinic
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Robin, Marie [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Godley, Lucy A. [Auteur]
University of Chicago
Drozd-Sokołowska, Joanna [Auteur]
Medical University of Warsaw - Poland
Włodarski, Marcin W. [Auteur]
St Jude Children's Research Hospital
Raj, Kavita [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Onida, Francesco [Auteur]
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Worel, Nina [Auteur]
Medizinische Universität Wien = Medical University of Vienna
Ciceri, Fabio [Auteur]
IRCCS Ospedale San Raffaele [Milan, Italy]
Carbacioglu, Selim [Auteur]
University Hospital Regensburg
Kenyon, Michelle [Auteur]
King's College Hospital [KCH]
Aljurf, Mahmoud [Auteur]
King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia] [KFSHRC]
Bonfim, Carmen [Auteur]
Makishima, Hideki [Auteur]
Kyoto University
Niemeyer, Charlotte [Auteur]

Fenaux, Pierre [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Zebisch, Armin [Auteur]
Medical University of Graz = Medizinische Universität Graz
Hamad, Nada [Auteur]
St. Vincent's Hospital, Sydney
Chalandon, Yves [Auteur]
Université de Genève = University of Geneva [UNIGE]
Hellström-Lindberg, Eva [Auteur]
Karolinska University Hospital [Stockholm]
Voso, Maria Teresa [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Mecucci, Cristina [Auteur]
Perugia General Hospital
Duarte, Fernando Barroso [Auteur]
Universidade Federal do Ceará = Federal University of Ceará [UFC]
Sebert, Marie [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Sicre De Fontbrune, Flore [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Soulier, Jean [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Shimamura, Akiko [Auteur]
Dana-Farber Cancer Institute [Boston]
Lindsley, R. Coleman [Auteur]
Dana-Farber Cancer Institute [Boston]
Maciejewski, Jarosław P. [Auteur]
Cleveland Clinic
Calado, Rodrigo T. [Auteur]
Universidade de São Paulo = University of São Paulo [USP]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Mclornan, Donal P. [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]

Journal title :

The Lancet Haematology

Abbreviated title :

Lancet Haematol

Publication date :

2023-10-30

ISSN :

2352-3026

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The recent application of whole exome or whole genome sequencing unveiled a plethora of germline variants predisposing to myeloid disorders, particularly myelodysplastic neoplasms. The presence of such variants in patients ...
Show more >The recent application of whole exome or whole genome sequencing unveiled a plethora of germline variants predisposing to myeloid disorders, particularly myelodysplastic neoplasms. The presence of such variants in patients with myelodysplastic syndromes has important clinical repercussions for haematopoietic stem-cell transplantation, from donor selection and conditioning regimen to graft-versus-host disease prophylaxis and genetic counselling for relatives. No international guidelines exist to harmonise management approaches to this particular clinical scenario. Moreover, the application of germline testing, and how this informs clinical decisions, differs according to the expertise of individual clinical practices and according to different countries, health-care systems, and legislations. Leveraging the global span of the European Society for Blood and Marrow Transplantation (EBMT) network, we took a snapshot of the current European situation on these matters by disseminating an electronic survey to EBMT centres experienced in myelodysplastic syndromes transplantation. An international group of haematologists, transplantation physicians, paediatricians, nurses, and experts in molecular biology and constitutional genetics with experience in myelodysplastic syndromes contributed to this Position Paper. The panel met during multiple online meetings to discuss the results of the EBMT survey and to establish suggested harmonised guidelines for such clinical situations, which are presented here.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-06T22:22:32Z
2024-03-22T08:50:55Z