Titre :

p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway.

Auteur(s) :

Fondevila, M. F. [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Novoa, E. [Auteur]
Gonzalez-Rellan, M. J. [Auteur]
Fernandez, U. [Auteur]
Heras, V. [Auteur]
Porteiro, B. [Auteur]
Parracho, T. [Auteur]
Dorta, V. [Auteur]
Riobello, C. [Auteur]
Da Silva Lima, N. [Auteur]
Seoane, S. [Auteur]
Garcia-Vence, M. [Auteur]
Chantada-Vazquez, M. P. [Auteur]
Bravo, S. B. [Auteur]
Senra, A. [Auteur]
Leiva, M. [Auteur]
Marcos, M. [Auteur]
Sabio, G. [Auteur]
Perez-Fernandez, R. [Auteur]
Dieguez, C. [Auteur]
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Schwaninger, M. [Auteur]
Woodhoo, A. [Auteur]
Martinez-Chantar, M. L. [Auteur]
Schwabe, R. [Auteur]
Cubero, F. J. [Auteur]
Varela-Rey, M. [Auteur]
Crespo, J. [Auteur]
Iruzubieta, P. [Auteur]
Nogueiras, R. [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]

Titre de la revue :

Cell Reports Medicine

Nom court de la revue :

Cell Rep Med

Numéro :

5

Pagination :

101401

Éditeur :

Cell Press Journal

Date de publication :

2024-02-12

ISSN :

2666-3791

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells (HSCs) have not yet been explored. ...
Lire la suite >The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells (HSCs) have not yet been explored. TAp63 is induced in HSCs from animal models and patients with liver fibrosis and its levels positively correlate with NAFLD activity score and fibrosis stage. In mice, genetic depletion of TAp63 in HSCs reduces the diet-induced liver fibrosis. In vitro silencing of p63 blunts TGF-β1-induced HSCs activation by reducing mitochondrial respiration and glycolysis, as well as decreasing acetyl CoA carboxylase 1 (ACC1). Ectopic expression of TAp63 induces the activation of HSCs and increases the expression and activity of ACC1 by promoting the transcriptional activity of HER2. Genetic inhibition of both HER2 and ACC1 blunt TAp63-induced activation of HSCs. Thus, TAp63 induces HSC activation by stimulating the HER2-ACC1 axis and participates in the development of liver fibrosis.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-02-17T22:04:48Z
2024-09-25T08:34:48Z