NOD-like receptors in asthma

Alvarez-Simon, Daniel; Ait Yahia, Saliha; de Nadai, Patricia; Audousset, Camille; Chamaillard, Mathias; Boneca, Ivo Gomperts; Tsicopoulos, Anne

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.3389/fimmu.2022.928886

PMID :

36189256

Titre :

NOD-like receptors in asthma

Auteur(s) :

Alvarez-Simon, Daniel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ait Yahia, Saliha [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
de Nadai, Patricia [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Audousset, Camille [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Chamaillard, Mathias [Auteur]

Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Boneca, Ivo Gomperts [Auteur]
Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall
Tsicopoulos, Anne [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Titre de la revue :

Frontiers in Immunology

Pagination :

928886

Éditeur :

Frontiers

Date de publication :

2022-09-14

ISSN :

1664-3224

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Immunologie

Résumé en anglais : [en]

Asthma is an extremely prevalent chronic inflammatory disease of the airway where innate and adaptive immune systems participate collectively with epithelial and other structural cells to cause airway hyperresponsiveness, ...
Lire la suite >Asthma is an extremely prevalent chronic inflammatory disease of the airway where innate and adaptive immune systems participate collectively with epithelial and other structural cells to cause airway hyperresponsiveness, mucus overproduction, airway narrowing, and remodeling. The nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of intracellular innate immune sensors that detect microbe-associated molecular patterns and damage-associated molecular patterns, well-recognized for their central roles in the maintenance of tissue homeostasis and host defense against bacteria, viruses and fungi. In recent times, NLRs have been increasingly acknowledged as much more than innate sensors and have emerged also as relevant players in diseases classically defined by their adaptive immune responses such as asthma. In this review article, we discuss the current knowledge and recent developments about NLR expression, activation and function in relation to asthma and examine the potential interventions in NLR signaling as asthma immunomodulatory therapies.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Déterminants moléculaires de sensibilisation à l'asthme allergique et innovation thérapeutique

Collections :