Titre :

Burden of Candida-related vascular graft infection: a nested-case control study.

Auteur(s) :

Caulier, Thomas [Auteur]
Centre Hospitalier Tourcoing
Senneville, Eric [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Sobocinski, Jonathan [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Leroy, Olivier [Auteur]
Centre Hospitalier Tourcoing
Patoz, Pierre [Auteur]
Centre Hospitalier Tourcoing
Blondiaux, Nicolas [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Georges, Hugues [Auteur]
Centre Hospitalier Tourcoing
Delannoy, Pierre-Yves [Auteur]
Centre Hospitalier Tourcoing
D'Elia, PierVito [Auteur]
Centre Hospitalier Tourcoing
Robineau, Olivier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Titre de la revue :

Infection

Nom court de la revue :

Infection

Éditeur :

Springer Link

Date de publication :

2024-02-13

ISSN :

1439-0973

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Purpose We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs). Methods We did a case–control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history ...
Lire la suite >Purpose We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs). Methods We did a case–control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined by a positive culture for Candida spp. in biological samples and controls were defined by a positive culture for bacterial strains only in biological samples. Risk factors for Candida-related VGIs were investigated using multivariate logistic regression. Mortality were compared using survival analysis. Results 16 Candida-related VGIs were matched to 64 bacterial-related VGIs. The two groups were comparable regarding medical history and clinical presentation. Candida-related VGIs were associated with bacterial strains in 88% (14/16). Gas/fluid-containing collection on abdominal CT scan and the presence of an aortic endoprosthesis were risk factors for Candida spp.-related VGIs [RRa 10.43 [1.81–60.21] p = 0.009 RRa and 6.46 [1.17–35.73] p = 0.03, respectively]. Candida-related VGIs were associated with a higher mortality when compared to bacterial-related VGIs (p = 0.002). Conclusions Candida-related VGIs are severe. Early markers of Candida spp. infection are needed to improve their outcome. The suspicion of aortic endoprosthesis infection may necessitate probabilistic treatment with antifungal agents.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2024-02-21T22:07:05Z
2024-05-15T08:11:21Z