Titre :

Polymorphism and conformations of mefenamic acid in supercritical carbon dioxide

Auteur(s) :

Oparin, M. D. [Auteur]
Vaksler, Y. A. [Auteur]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE]
Krestyaninov, M. A. [Auteur]
Idrissi, Nacer [Auteur]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement (LASIRE) - UMR 8516
Shishkina, S. V. [Auteur]
Kiselev, M. G. [Auteur]

Titre de la revue :

Journal of Supercritical Fluids

Nom court de la revue :

J. Supercrit. Fluids

Numéro :

152

Date de publication :

2019-11-02

ISSN :

0896-8446

Mot(s)-clé(s) en anglais :

Mefenamic acid
Polymorphism
Conformational manifold
Supercritical fluid technologies
IR spectroscopy
Raman spectroscopy

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

In this paper we have studied the conformations of mefenamic acid molecules in its saturated solution in supercritical carbon dioxide being in contact with bottom phase containing different polymorphs of mefenamic acid ...
Lire la suite >In this paper we have studied the conformations of mefenamic acid molecules in its saturated solution in supercritical carbon dioxide being in contact with bottom phase containing different polymorphs of mefenamic acid under isochoric heating conditions in the temperature range of 80–220 °C. For this purpose, we used in situ IR and Raman spectroscopy as well as micro IR and micro Raman spectroscopy and quantum chemical calculations. We have found that there is a correlation between the polymorphic modifications of the crystalline form of mefenamic acid and its conformers in CO2 fluid phase. The results of this work have shown that it is possible to monitor the polymorphic transformation of the crystalline phase of mefenamic acid by screening its molecular conformations in a fluid solution. This finding opens up the possibilities to manage the obtaining of certain polymorph of mefenamic acid with high purity degree from its fluid solution by means of variation of thermodynamic parameters of this solution.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

• Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement (LASIRE) - UMR 8516

Date de dépôt :

2024-02-28T23:16:17Z
2024-03-11T10:43:11Z