Title :

Encapsulation of a TRPM8 Agonist, WS12, in Lipid Nanocapsules Potentiates PC3 Prostate Cancer Cell Migration Inhibition through Channel Activation

Author(s) :

Grolez, G. [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Hammadi, M. [Auteur]
Institut Supérieur de l'Electronique et du Numérique - Lille [ISEN-Lille]
Barras, Alexandre [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
NanoBioInterfaces - IEMN [NBI - IEMN]
Gordienko, D. [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Slomianny, C. [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Völkel, P. [Auteur]
Plasticité Cellulaire et Cancer - U908 [CPAC]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Angrand, P. [Auteur]
Plasticité Cellulaire et Cancer - U908 [CPAC]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Pinault, M. [Auteur]
Niche, Nutrition, Cancer et métabolisme oxydatif [N2Cox]
Guimaraes, C. [Auteur]
Niche, Nutrition, Cancer et métabolisme oxydatif [N2Cox]
Potier-Cartereau, M. [Auteur]
Niche, Nutrition, Cancer et métabolisme oxydatif [N2Cox]
Prevarskaya, N. [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
NanoBioInterfaces - IEMN [NBI - IEMN]
Gkika, D. [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]

Journal title :

Scientific Reports

Publisher :

Nature Publishing Group

Publication date :

2019-12-01

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Biologie cellulaire

English abstract : [en]

In prostate carcinogenesis, expression and/or activation of the Transient Receptor Potential Melastatin 8 channel (TRPM8) was shown to block in vitro Prostate Cancer (PCa) cell migration. Because of their localization at ...
Show more >In prostate carcinogenesis, expression and/or activation of the Transient Receptor Potential Melastatin 8 channel (TRPM8) was shown to block in vitro Prostate Cancer (PCa) cell migration. Because of their localization at the plasma membrane, ion channels, such as TRPM8 and other membrane receptors, are promising pharmacological targets. The aim of this study was thus to use nanocarriers encapsulating a TRPM8 agonist to efficiently activate the channel and therefore arrest PCa cell migration. To achieve this goal, the most efficient TRPM8 agonist, WS12, was encapsulated into Lipid NanoCapsules (LNC). The effect of the nanocarriers on channel activity and cellular physiological processes, such as cell viability and migration, were evaluated in vitro and in vivo. These results provide a proof-of-concept support for using TRPM8 channel-targeting nanotechnologies based on LNC to develop more effective methods inhibiting PCa cell migration in zebrafish xenograft.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL