TRP Channels in Brain Tumors

Chinigò, Giorgia; Castel, Hélène; Chever, Oana; Gkika, Dimitra

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.3389/fcell.2021.617801

PMID :

33928077

Titre :

TRP Channels in Brain Tumors

Auteur(s) :

Chinigò, Giorgia [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Università degli studi di Torino = University of Turin [UNITO]
Castel, Hélène [Auteur]
Différenciation et communication neuronale et neuroendocrine [DC2N]
Chever, Oana [Auteur]
Différenciation et communication neuronale et neuroendocrine [DC2N]
Gkika, Dimitra [Directeur de publication]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Université de Lille

Titre de la revue :

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Pagination :

1-17

Éditeur :

Frontiers media

Date de publication :

2021-04-13

ISSN :

2296-634X

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant ...
Lire la suite >Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant therapy, GBM remains one of the most aggressive human cancers. GBM is a typical example of intra-heterogeneity modeled by different micro-environmental situations, one of the main causes of resistance to conventional treatments. The resistance to treatment is associated with angiogenesis, hypoxic and necrotic tumor areas while heterogeneity would accumulate during glioma cell invasion, supporting recurrence. These complex mechanisms require a focus on potential new molecular actors to consider new treatment options for gliomas. Among emerging and underexplored targets, transient receptor potential (TRP) channels belonging to a superfamily of non-selective cation channels which play critical roles in the responses to a number of external stimuli from the external environment were found to be related to cancer development, including glioma. Here, we discuss the potential as biological markers of diagnosis and prognosis of TRPC6, TRPM8, TRPV4, or TRPV1/V2 being associated with glioma patient overall survival. TRPs-inducing common or distinct mechanisms associated with their Ca 2+ -channel permeability and/or kinase function were detailed as involving miRNA or secondary effector signaling cascades in turn controlling proliferation, cell cycle, apoptotic pathways, DNA repair, resistance to treatment as well as migration/invasion. These recent observations of the key role played by TRPs such as TRPC6 in GBM growth and invasiveness, TRPV2 in proliferation and glioma-stem cell differentiation and TRPM2 as channel carriers of cytotoxic chemotherapy within glioma cells, should offer new directions for innovation in treatment strategies of high-grade glioma as GBM to overcome high resistance and recurrence.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :