Titre :

Lasting Symptoms After Esophageal Resection (LASER)

Auteur(s) :

Markar, Sheraz [Auteur]
Imperial College London
Karolinska Institutet [Stockholm]
Zaninotto, Giovanni [Auteur]
Castoro, Carlo [Auteur]
Johar, Asif [Auteur]
Lagergren, Pernilla [Auteur]
Karolinska University Hospital [Stockholm]
Elliott, Jessie [Auteur]
Gisbertz, Suzanne [Auteur]
Mariette, Christophe [Auteur]
Hôpital Claude Huriez [Lille]
Alfieri, Rita [Auteur]
Huddy, Jeremy [Auteur]
Sounderajah, Viknesh [Auteur]
Pinto, Eleonora [Auteur]
Scarpa, Marco [Auteur]
Università degli Studi di Messina = University of Messina [UniMe]
Klevebro, Fredrik [Auteur]
Sunde, Berit [Auteur]
Murphy, Conor [Auteur]
National University of Ireland Maynooth [Maynooth University]
Greene, Christine [Auteur]
Ravi, Narayanasamy [Auteur]
Piessen, Guillaume [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Brenkman, Hylke [Auteur]
Ruurda, Jelle [Auteur]
van Hillegersberg, Richard [Auteur]
Lagarde, Sjoerd [Auteur]
Wijnhoven, Bas [Auteur]
Pera, Manuel [Auteur]
Roig, José [Auteur]
Castro, Sandra [Auteur]
Matthijsen, Robert [Auteur]
Findlay, John [Auteur]
Antonowicz, Stefan [Auteur]
Maynard, Nick [Auteur]
Mccormack, Orla [Auteur]
Ariyarathenam, Arun [Auteur]
Sanders, Grant [Auteur]
Cheong, Edward [Auteur]
Jaunoo, Shameen [Auteur]
Allum, William [Auteur]
van Lanschot, Jan [Auteur]
Nilsson, Magnus [Auteur]
Reynolds, John [Auteur]
van Berge Henegouwen, Mark [Auteur]
Hanna, George [Auteur]

Titre de la revue :

Annals of Surgery

Pagination :

e392-e400

Éditeur :

Lippincott, Williams & Wilkins

Date de publication :

2022-02-11

ISSN :

0003-4932

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Cancer

Résumé en anglais : [en]

Objective: To identify the most prevalent symptoms and those with greatest impact upon health-related quality of life (HRQOL) among esophageal cancer survivors. Background: Long-term symptom burden after esophagectomy, and ...
Lire la suite >Objective: To identify the most prevalent symptoms and those with greatest impact upon health-related quality of life (HRQOL) among esophageal cancer survivors. Background: Long-term symptom burden after esophagectomy, and associations with HRQOL, are poorly understood. Patients and Methods: Between 2010 and 2016, patients from 20 European Centers who underwent esophageal cancer surgery, and were disease-free at least 1 year postoperatively were asked to complete LASER, EORTC-QLQ-C30, and QLQ-OG25 questionnaires. Specific symptom questionnaire items that were associated with poor HRQOL as identified by EORTC QLQ-C30 and QLQ-OG25 were identified by multivariable regression analysis and combined to form a tool. Results: A total of 876 of 1081 invited patients responded to the questionnaire, giving a response rate of 81%. Of these, 66.9% stated in the last 6 months they had symptoms associated with their esophagectomy. Ongoing weight loss was reported by 10.4% of patients, and only 13.8% returned to work with the same activities. Three LASER symptoms were correlated with poor HRQOL on multivariable analysis; pain on scars on chest (odds ratio (OR) 1.27; 95% CI 0.97–1.65), low mood (OR 1.42; 95% CI 1.15–1.77) and reduced energy or activity tolerance (OR 1.37; 95% CI 1.18–1.59). The areas under the curves for the development and validation datasets were 0.81 ± 0.02 and 0.82 ± 0.09 respectively. Conclusion: Two-thirds of patients experience significant symptoms more than 1 year after surgery. The 3 key symptoms associated with poor HRQOL identified in this study should be further validated, and could be used in clinical practice to identify patients who require increased support.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL