Title :

Slowly resorbable biosynthetic mesh: 2-year results in VHWG grade 3 hernia repair

Author(s) :

van Rooijen, M. [Auteur]
Tollens, T. [Auteur]
Jørgensen, L. [Auteur]
de Vries Reilingh, T. [Auteur]
Piessen, G. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Köckerling, F. [Auteur]
University Hospital Magdeburg
Miserez, M. [Auteur]
University Hospitals Leuven [Leuven]
Windsor, A. [Auteur]
Max Planck Institute for Chemical Ecology
Berrevoet, F. [Auteur]
Ghent University Hospital
Fortelny, R. [Auteur]
Dousset, B. [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hôpital Cochin [AP-HP]
Woeste, G. [Auteur]
van Westreenen, H. [Auteur]
Gossetti, F. [Auteur]
Lange, J. [Auteur]
Tetteroo, G. [Auteur]
Koch, A. [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Jeekel, J. [Auteur]

Journal title :

Hernia

Pages :

131-138

Publisher :

Springer Verlag

Publication date :

2021-07-19

ISSN :

1265-4906

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Abstract Introduction Information on the long-term performance of biosynthetic meshes is scarce. This study analyses the performance of biosynthetic mesh (Phasix™) over 24 months. Methods A prospective, international ...
Show more >Abstract Introduction Information on the long-term performance of biosynthetic meshes is scarce. This study analyses the performance of biosynthetic mesh (Phasix™) over 24 months. Methods A prospective, international European multi-center trial is described. Adult patients with a Ventral Hernia Working Group (VHWG) grade 3 incisional hernia larger than 10 cm 2 , scheduled for elective repair, were included. Biosynthetic mesh was placed in sublay position. Short-term outcomes included 3-month surgical site occurrences (SSO), and long-term outcomes comprised hernia recurrence, reoperation, and quality of life assessments until 24 months. Results Eighty-four patients were treated with biosynthetic mesh. Twenty-two patients (26.2%) developed 34 SSOs, of which 32 occurred within 3 months (primary endpoint). Eight patients (11.0%) developed a hernia recurrence. In 13 patients (15.5%), 14 reoperations took place, of which 6 were performed for hernia recurrence (42.9%), 3 for mesh infection (21.4%), and in 7 of which the mesh was explanted (50%). Compared to baseline, quality of life outcomes showed no significant difference after 24 months. Despite theoretical resorption, 10.7% of patients reported presence of mesh sensation in daily life 24 months after surgery. Conclusion After 2 years of follow-up, hernia repair with biosynthetic mesh shows manageable SSO rates and favorable recurrence rates in VHWG grade 3 patients. No statistically significant improvement in quality of life or reduction of pain was observed. Few patients report lasting presence of mesh sensation. Results of biosynthetic mesh after longer periods of follow-up on recurrences and remodeling will provide further valuable information to make clear recommendations. Trial registration Registered on clinicaltrials.gov (NCT02720042), March 25, 2016.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL