Title :

Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B

Author(s) :

Carpenter, Jerome [Auteur]
Wang, Yang [Auteur]
Dana-Farber Cancer Institute [Boston]
Gupta, Richa [Auteur]
Vanderbilt University Medical Center [Nashville]
Li, Yuanli [Auteur]
Haridass, Prashamsha [Auteur]
Subramani, Durai [Auteur]
Reidel, Boris [Auteur]
Morton, Lisa [Auteur]
Ridley, Caroline [Auteur]
University of Manchester [Manchester]
O’neal, Wanda [Auteur]
Buisine, Marie-Pierre [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ehre, Camille [Auteur]
Thornton, David [Auteur]
University of Manchester [Manchester]
Kesimer, Mehmet [Auteur]

Journal title :

Proceedings of the National Academy of Sciences of the United States of America

Publisher :

National Academy of Sciences

Publication date :

2021-09-21

ISSN :

0027-8424

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Significance Gel-forming mucins, MUC5AC and MUC5B, are the essential components of the protective mucus layer of the lungs. MUC5B is crucial for lung innate defense, and MUC5AC is generally secreted disproportionately in ...
Show more >Significance Gel-forming mucins, MUC5AC and MUC5B, are the essential components of the protective mucus layer of the lungs. MUC5B is crucial for lung innate defense, and MUC5AC is generally secreted disproportionately in response to cigarette smoke and allergens. MUC5AC’s role in airway defense and chronic airway disease pathogenesis and how this emerges from its macromolecular assembly/gel-making properties are not known. We demonstrate MUC5AC binds significantly more to hydrophobic surfaces and forms stiffer and more viscoelastic layers compared to MUC5B. Also, MUC5AC forms higher-order oligomers in addition to dimers. These observations may generate insight into why/how MUC5AC forms a stagnant, “tethered” mucus layer in muco-obstructive lung diseases and could guide the development of strategies to intervene with more effective therapeutic agents.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL