Title :

Benefits of cryopreserved human amniotic membranes in association with conventional treatments in the management of full‐thickness burns

Author(s) :

Hatzfeld, Anne‐sophie [Auteur]
Pasquesoone, Louise [Auteur]
Germain, Nicolas [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Université de Lille
Danzé, Pierre‐marie [Auteur]
Drucbert, Anne‐sophie [Auteur]
Tardivel, Meryem [Auteur]
Bongiovanni, Antonino [Auteur]
Duquennoy-Martinot, Véronique [Auteur]
Guerreschi, Pierre [Auteur]
Marchetti, Philippe [Auteur]

Journal title :

International Wound Journal

Pages :

1354-1364

Publisher :

Wiley

Publication date :

2019-08-19

ISSN :

1742-4801

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

English abstract : [en]

Abstract The use of split‐thickness skin autografts (STSA) with dermal substitutes is the gold standard treatment for third‐degree burn patients. In this article, we tested whether cryopreserved amniotic membranes could ...
Show more >Abstract The use of split‐thickness skin autografts (STSA) with dermal substitutes is the gold standard treatment for third‐degree burn patients. In this article, we tested whether cryopreserved amniotic membranes could be beneficial to the current treatments for full‐thickness burns. Swines were subjected to standardised full‐thickness burn injuries, and then were randomly assigned to treatments: (a) STSA alone; (b) STSA associated with the dermal substitute, Matriderm; (c) STSA plus human amniotic membrane (HAM); and (d) STSA associated with Matriderm plus HAM. Clinical and histological assessments were performed over time. We also reported the clinical use of HAM in one patient. The addition of HAM to classic treatments reduced scar contraction. In the presence of HAM, skin wound healing displayed high elasticity and histological examination showed a dense network of long elastic fibres. The presence of HAM increased dermal neovascularization, but no effect was observed on the recruitment of inflammatory cells to the wound. Moreover, the use of HAM with classical treatments in one human patient revealed a clear benefit in terms of elasticity. These results give initial evidence to consider the clinical application of HAM to avoid post‐burn contractures and therefore facilitate functional recovery after deep burn injury.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL