Title :

The short‐ and long‐term outcomes of pancreaticoduodenectomy for cancer in child a patients are acceptable: A patient‐control study from the Surgical French Association report for pancreatic surgery

Author(s) :

Regimbeau, Jean‐marc [Auteur]
Université de Picardie Jules Verne [UPJV]
Rebibo, Lionel [Auteur]
Simplification des soins chez les patients complexes - UR UPJV 7518 [SSPC]
Chirurgie digestive [CHU Amiens]
Dokmak, Safi [Auteur]
Service de chirurgie hepato-pancreato-biliaire
Boher, Jean‐marie [Auteur]
Sauvanet, Alain [Auteur]
Service de chirurgie hepato-pancreato-biliaire
Chopin-Laly, Xavier [Auteur]
Adham, Mustapha [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Lesurtel, Mickaël [Auteur]
Hospices Civils de Lyon [HCL]
University hospital of Zurich [Zurich]
Bigourdan, Jean‐marc [Auteur]
Truant, Stéphanie [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Pruvot, François‐rené [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Ortega-Deballon, Pablo [Auteur]
Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon)
Lipides - Nutrition - Cancer (U866) [LNC]
Paye, François [Auteur]
CHU Saint-Antoine [AP-HP]
Bachellier, Philippe [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Delpero, Jean‐robert [Auteur]

Journal title :

JOURNAL OF SURGICAL ONCOLOGY

Pages :

776-783

Publisher :

Wiley-Blackwell

Publication date :

2015-02-08

ISSN :

0022-4790

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background On the basis of now dated studies, cirrhosis is usually considered to be a contraindication in pancreatoduodenectomy (PD) for adenocarcinoma of the pancreatic head (APH). Objective Examine the outcomes of PD for ...
Show more >Background On the basis of now dated studies, cirrhosis is usually considered to be a contraindication in pancreatoduodenectomy (PD) for adenocarcinoma of the pancreatic head (APH). Objective Examine the outcomes of PD for APH in the presence of cirrhosis. Methods Retrospective, multicenter study of cirrhotic patients with APH having undergone PD between January 2004 and March 2012. Cirrhotic patients were matched 1:2 for demographic, surgical and histologic criteria with non‐cirrhotic patients. Primary endpoint was morbidity and mortality. Secondary endpoints were surgical parameters, morbidity related to pancreatic surgery and cirrhosis, and follow‐up. Results We included 35 patients with cirrhosis. Twenty‐four patients (69%) were Child A and none were Child C. The Child A cirrhotic patients and non‐cirrhotic patients respectively had complication rates of 79% vs. 43% ( P = 0.002), major complication rates of 33% vs. 21% ( P = 0.26), pancreatic fistula rates of 13% vs. 9% ( P = 0.57), post‐operative mortality of 4% vs. 5% ( P = 0.94), 3‐year overall survival rates of 44% vs. 50% ( P = 0.46). All Child B cirrhotic patients experienced post‐operative complications. Conclusion Pancreatoduodenectomy for APH was possible in Child A cirrhotic patients with a mortality and long‐term outcomes equivalent to non‐cirrhotic patients. Child B cirrhosis remains a clear contraindication to surgery. J. Surg. Oncol. 2015 111:776–783 . © 2015 Wiley Periodicals, Inc. J. Surg. Oncol. 2015 111:776–783 . © 2015 Wiley Periodicals, Inc.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL