Titre :

Morbid obesity increases death and dropout from the liver transplantation waiting list: A prospective cohort study

Auteur(s) :

Delacôte, Claire [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Favre, Mathilde [Auteur]
Université Grenoble Alpes - UFR Médecine [UGA UFRM]
El Amrani, Medhi [Auteur]
Ningarhari, Massih [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Lemaitre, Elise [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Ntandja-Wandji, Line Carolle [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Bauvin, Pierre [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Boleslawski, Emmanuel [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Millet, Guillaume [Auteur]
Institut universitaire de France [IUF]
Laboratoire Interuniversitaire de Biologie de la Motricité [LIBM]
Truant, Stéphanie [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Mathurin, Philippe [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Louvet, Alexandre [Auteur]
Hôpital Claude Huriez [Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Canva, Valérie [Auteur]
Hôpital Claude Huriez [Lille]
Lebuffe, Gilles [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Pruvot, François René [Auteur]
Dharancy, Sébastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Lassailly, Guillaume [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hôpital Claude Huriez [Lille]

Titre de la revue :

United European Gastroenterology Journal

Pagination :

396-408

Éditeur :

SAGE Publications

Date de publication :

2022-04-26

ISSN :

2050-6406

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Abstract Liver transplant (LT) candidates with a body mass index (BMI) over 40 kg/m 2 have lower access to a liver graft without clear explanation. Thus, we studied the impact of obesity on the waiting list (WL) and aimed ...
Lire la suite >Abstract Liver transplant (LT) candidates with a body mass index (BMI) over 40 kg/m 2 have lower access to a liver graft without clear explanation. Thus, we studied the impact of obesity on the waiting list (WL) and aimed to explore graft proposals and refusal. Method Data between January 2007 and December 2017 were extracted from the French prospective national database: CRISTAL. Competing risk analyses were performed to evaluate predictors of receiving LT. Competitive events were (1) death/WL removal for disease aggravation or (2) improvement. The link between grade obesity, grafts propositions, and reason for refusal was studied. Results 15,184 patients were analysed: 10,813 transplant, 2847 death/dropout for aggravation, 748 redirected for improvement, and 776 censored. Mortality/dropout were higher in BMI over 35 (18% vs. 14% 1 year after listing) than in other candidates. In multivariate analysis, BMI>35, age, hepatic encephalopathy, and ascites were independent predictors of death/dropout. Candidates with a BMI ≥ 35 kg/m 2 had reduced access to LT, without differences in graft proposals. However, grafts refusal was more frequent especially for ‘morphological incompatibility’ (14.9% vs. 12.7% p < 0.01). Conclusion BMI over 35 kg/m 2 reduces access to LT with increased risk of dropout and mortality. Increased mortality and dropout could be due to a lower access to liver graft secondary to increased graft refusal for morphological incompatibility.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL