Title :

Prognostic impact of number of induction courses to attain complete remission in patients with acute myeloid leukemia transplanted with either a matched sibling or human leucocyte antigen 10/10 or 9/10 unrelated donor: An Acute Leukemia Working Party European Society for Blood and Marrow Transplantation study.

Author(s) :

Loke, Justin [Auteur]
Labopin, Myriam [Auteur]
Sorbonne Université [SU]
Craddock, Charles [Auteur]
Socié, Gérard [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Gedde-Dahl, Tobias [Auteur]
Blaise, Didier [Auteur]
Centre de Recherche en Cancérologie de Marseille [CRCM]
Forcade, Edouard [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Salmenniemi, Urpu [Auteur]
Huynh, Anne [Auteur]
Institut Universitaire du Cancer de Toulouse - Oncopole [IUCT Oncopole - UMR 1037]
Versluis, Jurjen [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Labussière-Wallet, Hélène [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Maertens, Johan [Auteur]
Passweg, Jakob [Auteur]
Bulabois, Claude Eric [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Gabellier, Ludovic [Auteur]
Hôpital Lapeyronie [CHU Montpellier]
Mielke, Stephan [Auteur]
Castilla-Llorente, Cristina [Auteur]
Institut Gustave Roussy [IGR]
Deconinck, Eric [Auteur]
Université de Franche-Comté [UFC]
Brissot, Eolia [Auteur]
Sorbonne Université [SU]
Nagler, Arnon [Auteur]
Ciceri, Fabio [Auteur]
Mohty, Mohamad [Auteur]
Sorbonne Université [SU]

Journal title :

Cancer

Abbreviated title :

Cancer

Volume number :

130

Pages :

2642-2651

Publication date :

2024-08-01

ISSN :

1097-0142

English keyword(s) :

AML
induction chemotherapy
MRD
stem cell transplant

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction For the majority of patients with acute myeloid leukemia (AML) an allogeneic stem cell transplant (SCT) in first complete remission (CR) is preferred. However, whether the number of courses required to achieve ...
Show more >Introduction For the majority of patients with acute myeloid leukemia (AML) an allogeneic stem cell transplant (SCT) in first complete remission (CR) is preferred. However, whether the number of courses required to achieve CR has a prognostic impact is unclear. It is unknown which factors remain important in patients requiring more than one course of induction to attain remission. Methods This Acute Leukaemia Working Party study from the European Society for Blood and Marrow Transplantation identified adults who received an allograft in first CR from either a fully matched sibling or 10/10 or 9/10 human leucocyte antigen (HLA)-matched unrelated donor (HLA-A, HLA-B, HLA-C, HLA-DR, or HLA-DQ). Univariate and multivariate analyses were undertaken to identify the prognostic impact of one or two courses of induction to attain CR. Results A total of 4995 patients were included with 3839 (77%) patients attaining a CR following one course of induction chemotherapy (IND1), and 1116 patients requiring two courses (IND2) to attain CR. IND2 as compared to IND1 was a poor prognostic factor in a univariate analysis and remained so in a multivariate Cox model, resulting in an increased hazard ratio of relapse (1.38; 95% confidence interval [CI], 1.16–1.64; p = .0003) and of death (1.27; 95% CI, 1.09–1.47; p = .002). Adverse prognostic factors in a multivariate analysis of the outcomes of patients requiring IND2 included age, FLT3-ITD, adverse cytogenetics, and performance status. Pretransplant measurable residual disease retained a prognostic impact regardless of IND1 or IND2. Conclusion Initial response to chemotherapy as determined by number of courses to attain CR, retained prognostic relevance even following SCT in CR.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-05-06T21:23:32Z
2024-08-19T13:22:38Z