Titre :

Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review

Auteur(s) :

Fernández, Óscar [Auteur]
Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain]
Universidad de Málaga [Málaga] = University of Málaga [Málaga]
Soelberg Sorensen, Per [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Copenhagen University Hospital
Comi, Giancarlo [Auteur]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
Vermersch, Patrick [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Hartung, Hans-Peter [Auteur]
The University of Sydney
Palacky University Olomouc
Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
Leocani, Letizia [Auteur]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
Berger, Thomas [Auteur]
Medizinische Universität Wien = Medical University of Vienna
Van Wijmeersch, Bart [Auteur]
Hasselt University [UHasselt]
Noorderhart Mariaziekenhuis [Pelt, Belgique]
Oreja-Guevara, Celia [Auteur]
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] [IdISSC]
Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] [UCM]

Titre de la revue :

Frontiers in Immunology

Nom court de la revue :

Front Immunol

Numéro :

15

Pagination :

1379538

Éditeur :

Frontiers

Date de publication :

2024-04-05

ISSN :

1664-3224

Mot(s)-clé(s) en anglais :

multiple sclerosis
aging
management
disease-modifying treatments
symptomatic treatment

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Multiple Sclerosis (MS) management in individuals aged 55 and above presents unique challenges due to the complex interaction between aging, comorbidities, immunosenescence, and MS pathophysiology. This comprehensive review ...
Lire la suite >Multiple Sclerosis (MS) management in individuals aged 55 and above presents unique challenges due to the complex interaction between aging, comorbidities, immunosenescence, and MS pathophysiology. This comprehensive review explores the evolving landscape of MS in older adults, including the increased incidence and prevalence of MS in this age group, the shift in disease phenotypes from relapsing-remitting to progressive forms, and the presence of multimorbidity and polypharmacy. We aim to provide an updated review of the available evidence of disease-modifying treatments (DMTs) in older patients, including the efficacy and safety of existing therapies, emerging treatments such as Bruton tyrosine kinase (BTKs) inhibitors and those targeting remyelination and neuroprotection, and the critical decisions surrounding the initiation, de-escalation, and discontinuation of DMTs. Non-pharmacologic approaches, including physical therapy, neuromodulation therapies, cognitive rehabilitation, and psychotherapy, are also examined for their role in holistic care. The importance of MS Care Units and advance care planning are explored as a cornerstone in providing patient-centric care, ensuring alignment with patient preferences in the disease trajectory. Finally, the review emphasizes the need for personalized management and continuous monitoring of MS patients, alongside advocating for inclusive study designs in clinical research to improve the management of this growing patient demographic.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Neuroinflammation & Multiple Sclerosis (NEMESIS)

Date de dépôt :

2024-05-06T22:27:09Z
2025-03-07T16:00:10Z