Titre :

Blood Neurofilament Levels Predict Cognitive Decline across the Alzheimer's Disease Continuum.

Auteur(s) :

Lehmann, S. [Auteur]
Schraen, Susanna [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Vidal, J. S. [Auteur]
Blanc, F. [Auteur]
Paquet, C. [Auteur]
Allinquant, B. [Auteur]
Bombois, Stephanie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Gabelle, A. [Auteur]
Delaby, C. [Auteur]
Hanon, O. [Auteur]

Titre de la revue :

International Journal of Molecular Sciences

Nom court de la revue :

Int J Mol Sci

Numéro :

24

Éditeur :

MDPI

Date de publication :

2023-12-24

ISSN :

1422-0067

Mot(s)-clé(s) en anglais :

Alzheimer's disease
neurofilament light chain
blood
cognitive decline

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Neurofilament light chain (NfL) is a potential diagnostic and prognostic plasma biomarker for numerous neurological diseases including Alzheimer’s disease (AD). In this study, we investigated the relationship between ...
Lire la suite >Neurofilament light chain (NfL) is a potential diagnostic and prognostic plasma biomarker for numerous neurological diseases including Alzheimer’s disease (AD). In this study, we investigated the relationship between baseline plasma concentration of Nfl and Mild Cognitive Impairment in participants who did and did not have a clinically determined diagnosis of dementia by the end of the three-year study. Additionally, we explored the connection between baseline plasma concentration of NfL and AD dementia patients, considering their demographics, clinical features, and cognitive profiles. A total of 350 participants from the Biomarker of AmyLoid pepTide and AlZheimer’s diseAse Risk (BALTAZAR) multicenter prospective study were investigated: 161 AD dementia participants and 189 MCI participants (of which 141 had amnestic MCI and 48 non-amnestic MCI). Plasma biomarkers were measured at baseline and the progression of clinical and cognitive profiles was followed over the three years of follow-up. Baseline plasma NfL concentration increased across the Alzheimer’s disease continuum with a mean NfL value of 17.1 ng/mL [SD = 6.1] in non-amnestic MCI, 20.7 ng/mL [SD = 12.0] in amnestic MCI, and 23.1 ng/mL [SD = 22.7] in AD dementia patients. Plasma NfL concentration correlated with age, body mass index (BMI), and global cognitive performance and decline, as measured by the Mini-Mental State Examination (MMSE). MMSE scores decreased in parallel with increasing plasma NfL concentration, independently of age and BMI. However, NfL concentration did not predict MCI participants’ conversion to dementia within three years. Discussion: Baseline plasma NfL concentration is associated with cognitive status along the AD continuum, suggesting its usefulness as a potential informative biomarker for cognitive decline follow-up in patients.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-05-06T22:47:41Z
2024-09-18T08:36:22Z