Titre :

Predictive Value of Immune Cells in the Risk of Gestational Diabetes Mellitus: A Pilot Study

Auteur(s) :

Fagninou, Adnette [Auteur]
Ecole Polytechnique d'Abomey Calavi [EPAC]
Institut des Sciences Biomédicales Appliquées [ISBA]
Nekoua, Magloire Pandoua [Auteur]
186678|||Institut des Sciences Biomédicales Appliquées [ISBA] (VALID)
Fiogbe, Salomon Ezéchiel M. [Auteur]
Ecole Polytechnique d'Abomey Calavi [EPAC]
Moutaïrou, Kabirou [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Yessoufou, Akadiri [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]

Titre de la revue :

Frontiers in Clinical Diabetes and Healthcare

Nom court de la revue :

Front. Clin. Diabet. Healthc.

Numéro :

3

Pagination :

819164

Éditeur :

Frontiers

Date de publication :

2022-02-18

ISSN :

2673-6616

Mot(s)-clé(s) en anglais :

immune cells
biochemical parameters
gestational diabetes mellitus
predictive value
lymphocyte
HDL-cholesterol

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Aims: Immunological and biochemical parameters are gaining more and more importance in the prognosis of diabetes and its complications. Here, we assessed the predictive power of immune cells correlated with biochemical ...
Lire la suite >Aims: Immunological and biochemical parameters are gaining more and more importance in the prognosis of diabetes and its complications. Here, we assessed the predictive power of immune cells correlated with biochemical parameters in gestational diabetes mellitus (GDM). Materials and Methods: Immune cells and serum biochemical parameters were determined in women with GDM and pregnant controls. Receiver operating characteristics (ROC) curve analyses were conducted to assess the optimal cutoff and value of ratios of immune cells to biochemical parameters for predicting GDM. Results: Blood glucose, total cholesterol, LDL-cholesterol and triglycerides were significantly increased whereas HDL-cholesterol decreased in women with GDM compared to pregnant controls. Glycated hemoglobin, creatinine, transaminase activities did not significantly differ between both groups. Total leukocyte, lymphocyte and platelet numbers were significantly high in women with GDM. Correlation tests showed that ratios of lymphocyte/HDL-C, monocyte/HDL-C and granulocyte/HDL-C were significantly higher in women with GDM than in pregnant controls (p = 0.001; p = 0.009 and p = 0.004 respectively). Women with a lymphocyte/HDL-C ratio greater than 3.66 had a 4-fold increased risk of developing GDM than those with lower ratios (odds ratio 4.00; 95% CI: 1.094 – 14.630; p=0.041). Conclusion: Our study showed that ratios of lymphocyte, monocyte and granulocyte to HDL-C might represent valuable biomarkers for GDM and in particular, lymphocyte/HDL-C ratio exhibited a strong predictive power for GDM risk.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Autres travaux scientifiques

Date de dépôt :

2024-05-24T21:01:59Z
2024-09-27T08:14:14Z
2024-09-27T08:41:18Z