Chemical exchange of labile protons by ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations
Author(s) :
Welton, C. [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Raval, Parth [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Trebosc, Julien [Auteur]
Institut Michel Eugène Chevreul - FR 2638 [IMEC]
Reddy, Manjunatha [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Raval, Parth [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Trebosc, Julien [Auteur]
Institut Michel Eugène Chevreul - FR 2638 [IMEC]
Reddy, Manjunatha [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Journal title :
Chem. Commun.
Abbreviated title :
Chem. Commun.
Volume number :
58
Pages :
11551-11554
Publication date :
2022-10-07
ISSN :
1359-7345
HAL domain(s) :
Chimie/Chimie inorganique
English abstract : [en]
Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are ...
Show more >Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by 1H–2H isotope correlation NMR spectroscopy (iCOSY). A minuscule concentration of dopamine, 5 wt% or ∼100 μg, in a solid formulation can be detected by 2H NMR at 28.2 T (1H, 1200 MHz) in under a minute.Show less >
Show more >Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by 1H–2H isotope correlation NMR spectroscopy (iCOSY). A minuscule concentration of dopamine, 5 wt% or ∼100 μg, in a solid formulation can be detected by 2H NMR at 28.2 T (1H, 1200 MHz) in under a minute.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois
CNRS
Centrale Lille
ENSCL
Univ. Artois
Collections :
Research team(s) :
RMN et matériaux inorganiques (RM2I)
Submission date :
2024-05-29T21:10:02Z
2024-06-07T07:15:10Z
2024-06-07T07:15:10Z
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