Title :

Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations

Author(s) :

Welton, C. [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Raval, Parth [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Trebosc, Julien [Auteur]
Institut Michel Eugène Chevreul - FR 2638 [IMEC]
Reddy, Manjunatha [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Journal title :

Chem. Commun.

Abbreviated title :

Chem. Commun.

Volume number :

58

Pages :

11551-11554

Publication date :

2022-10-07

ISSN :

1359-7345

HAL domain(s) :

Chimie/Chimie inorganique

English abstract : [en]

Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are ...
Show more >Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by 1H–2H isotope correlation NMR spectroscopy (iCOSY). A minuscule concentration of dopamine, 5 wt% or ∼100 μg, in a solid formulation can be detected by 2H NMR at 28.2 T (1H, 1200 MHz) in under a minute.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

RMN et matériaux inorganiques (RM2I)

Submission date :

2024-05-29T21:10:02Z
2024-06-07T07:15:10Z