Titre :

The impact of cirrhosis on short and long postoperative outcomes after distal pancreatectomy

Auteur(s) :

Coinsin, Benjamin [Auteur]
Durin, Thibault [Auteur]
Marchese, Ugo [Auteur]
Hôpital Cochin [AP-HP]
Sauvanet, Alain [Auteur]
Hôpital Beaujon [AP-HP]
Dokmak, Safi [Auteur]
Hôpital Beaujon [AP-HP]
Cherkaoui, Zineb [Auteur]
L'Institut hospitalo-universitaire de Strasbourg [IHU Strasbourg]
Simplification des soins chez les patients complexes - UR UPJV 7518 [SSPC]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Institut de Recherche sur les Maladies Virales et Hépatiques [IVH]
Fuks, David [Auteur]
Hôpital Cochin [AP-HP]
Laurent, Christophe [Auteur]
Hôpital Haut-Lévêque - CHU de Bordeaux [Centre médico chirurgical Magellan]
Magallon, Cloe [Auteur]
Institut Paoli-Calmettes [IPC]
Aix-Marseille Université - École de médecine [AMU SMPM MED]
Turrini, Olivier [Auteur]
Sulpice, Laurent [Auteur]
Centre Hospitalier Universitaire [Rennes]
Oncogenesis, Stress, Signaling [OSS]
Robin, Fabien [Auteur]
Centre Hospitalier Universitaire [Rennes]
H2P2 - Histo Pathologie Hight Precision [H2P2]
Oncogenesis, Stress, Signaling [OSS]
Bachellier, Philippe [Auteur]
Hôpital de Hautepierre [Strasbourg]
Addeo, Piettro [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Birnbaum, David Jérémie [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Roussel, Edouard [Auteur]
Service de Chirurgie Digestive [CHU Rouen]
Schwarz, Lilian [Auteur]
Service de Chirurgie Digestive [CHU Rouen]
Regimbeau, Jean-Marc [Auteur]
Chirurgie digestive [CHU Amiens]
Simplification des soins chez les patients complexes - UR UPJV 7518 [SSPC]
Piessen, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Liddo, Guido [Auteur]
Girard, Edouard [Auteur]
Cailliau, Émeline [Auteur]
Truant, Stéphanie [Auteur]
El Amrani, Mehdi [Auteur]

Titre de la revue :

Surgery

Pagination :

447-454

Éditeur :

Elsevier

Date de publication :

2024-05

ISSN :

0039-6060

Mot(s)-clé(s) en anglais :

INTERNATIONAL STUDY-GROUP
PORTAL-VEIN THROMBOSIS
RISK-FACTORS
LIVER-CIRRHOSIS
ABDOMINAL OPERATIONS
SINGLE-INSTITUTION
SURGERY
SPLENECTOMY
MORTALITY
ADENOCARCINOMA

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Chirurgie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Hépatologie et Gastroentérologie

Résumé en anglais : [en]

Background: The impact of cirrhosis on the postoperative outcomes of distal pancreatectomy is yet to be reported. We aimed to evaluate the outcomes of distal pancreatectomy in patients with cirrhosis.Methods: We conducted ...
Lire la suite >Background: The impact of cirrhosis on the postoperative outcomes of distal pancreatectomy is yet to be reported. We aimed to evaluate the outcomes of distal pancreatectomy in patients with cirrhosis.Methods: We conducted a retrospective, multicentric study patients with cirrhosis who underwent planned distal pancreatectomy between 2008 and 2020 in French high volume centers. Patients with cirrhosis were matched 1:4 for demographic, surgical, and histologic criteria with patients without cirrhosis. The primary endpoint was severe morbidity (Clavien-Dindo grade ≥III). The secondary endpoints were postoperative complications, specifically related to cirrhosis and pancreatic surgery, and survival for patients with pancreatic adenocarcinoma.Results: Overall, 32 patients with cirrhosis were matched with 128 patients without cirrhosis. Most patients (93.5%) had Child-Pugh A cirrhosis. The severe morbidity rate after distal pancreatectomy was higher in patients with cirrhosis than in those without cirrhosis (28.13% vs 25.75%, P = .11. The operative time was significantly longer in the cirrhotic group compared with controls (P = .01). However, patients with and without cirrhosis had comparable blood loss and conversion rates. Postoperatively, the two groups had similar rates of pancreatic fistula, hemorrhage, reoperation, postoperative mortality, and survival rates at 1, 3, and 5 years.Conclusion: The current study suggests that distal pancreatectomy in high-volume centers is feasible for patients with compensated cirrhosis.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL