Prolactin levels in functional hypothalamic ...
Document type :
Article dans une revue scientifique: Article original
PMID :
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Title :
Prolactin levels in functional hypothalamic amenorrhea: a retrospective case-control study.
Author(s) :
Selzer, C. [Auteur]
Ott, J. [Auteur]
Dewailly, Didier [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Marculescu, R. [Auteur]
Steininger, J. [Auteur]
Hager, M. [Auteur]
Ott, J. [Auteur]
Dewailly, Didier [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Marculescu, R. [Auteur]
Steininger, J. [Auteur]
Hager, M. [Auteur]
Journal title :
Archives of Gynecology and Obstetrics
Abbreviated title :
Arch Gynecol Obstet
Volume number :
309
Pages :
651–658
Publication date :
2023-11-19
ISSN :
1432-0711
English keyword(s) :
Hypogonadotropic hypogonadism
Prolactin
Stress
Polycystic ovary syndrome
Prolactin
Stress
Polycystic ovary syndrome
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Purpose
Functional hypothalamic amenorrhea (FHA) is due to hypothalamic dysregulation. Literature lacks data about prolactin in FHA women, although both prolactin levels and FHA are associated with stress. Moreover, ...
Show more >Purpose Functional hypothalamic amenorrhea (FHA) is due to hypothalamic dysregulation. Literature lacks data about prolactin in FHA women, although both prolactin levels and FHA are associated with stress. Moreover, polycystic ovarian morphology is common in FHA and there is an association between FHA and polycystic ovary syndrome. Thus, the aim of this study was to assess prolactin levels in FHA patients and controls with a special focus on factors influencing prolactin levels, that could be considered as “sensors” of the hypothalamic–pituitary dysregulation. Methods In a retrospective cohort study, 140 women with clearly defined FHA were compared to 70 healthy, normally ovulating women matched for age. The main outcome parameter was prolactin. Factors associated with prolactin levels > 12 µg/L were tested using a multivariable binary logistic regression model. Results The median prolactin level was 11.5 µg/L (interquartile range, IQR 7.5–14.4), which was similar to the control group (median 10.7, IQR 8.3–14.5; p = 0.065). Only two women had hyperprolactinemia (prolactin > 25 µg/L; 1.4%). In a multivariable binary logistic regression model eating disorder (odds ratio, OR 0.206; p = 0.040), excessive exercise (OR 0.280; p = 0.031) and TSH (OR 1.923; p = 0.020) were significantly associated with prolactin levels > 12 µg/L. Conclusion Women with FHA have similar prolactin levels to healthy age-matched individuals. Eating disorders and excessive exercise where associated with prolactin levels < 12 µg/L, in contrast to TSH.Show less >
Show more >Purpose Functional hypothalamic amenorrhea (FHA) is due to hypothalamic dysregulation. Literature lacks data about prolactin in FHA women, although both prolactin levels and FHA are associated with stress. Moreover, polycystic ovarian morphology is common in FHA and there is an association between FHA and polycystic ovary syndrome. Thus, the aim of this study was to assess prolactin levels in FHA patients and controls with a special focus on factors influencing prolactin levels, that could be considered as “sensors” of the hypothalamic–pituitary dysregulation. Methods In a retrospective cohort study, 140 women with clearly defined FHA were compared to 70 healthy, normally ovulating women matched for age. The main outcome parameter was prolactin. Factors associated with prolactin levels > 12 µg/L were tested using a multivariable binary logistic regression model. Results The median prolactin level was 11.5 µg/L (interquartile range, IQR 7.5–14.4), which was similar to the control group (median 10.7, IQR 8.3–14.5; p = 0.065). Only two women had hyperprolactinemia (prolactin > 25 µg/L; 1.4%). In a multivariable binary logistic regression model eating disorder (odds ratio, OR 0.206; p = 0.040), excessive exercise (OR 0.280; p = 0.031) and TSH (OR 1.923; p = 0.020) were significantly associated with prolactin levels > 12 µg/L. Conclusion Women with FHA have similar prolactin levels to healthy age-matched individuals. Eating disorders and excessive exercise where associated with prolactin levels < 12 µg/L, in contrast to TSH.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-06-22T21:36:05Z
2024-07-08T12:52:07Z
2024-07-08T12:52:07Z
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