Prolactin levels in functional hypothalamic amenorrhea: a retrospective case-control study.

Selzer, C.; Ott, J.; Dewailly, Didier; Marculescu, R.; Steininger, J.; Hager, M.

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00404-023-07277-1

PMID :

37957366

URL permanente :

http://hdl.handle.net/20.500.12210/115406

Titre :

Prolactin levels in functional hypothalamic amenorrhea: a retrospective case-control study.

Auteur(s) :

Selzer, C. [Auteur]
Ott, J. [Auteur]
Dewailly, Didier [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Marculescu, R. [Auteur]
Steininger, J. [Auteur]
Hager, M. [Auteur]

Titre de la revue :

Archives of Gynecology and Obstetrics

Nom court de la revue :

Arch Gynecol Obstet

Numéro :

309

Pagination :

651–658

Date de publication :

2023-11-19

ISSN :

1432-0711

Mot(s)-clé(s) en anglais :

Hypogonadotropic hypogonadism
Prolactin
Stress
Polycystic ovary syndrome

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Purpose Functional hypothalamic amenorrhea (FHA) is due to hypothalamic dysregulation. Literature lacks data about prolactin in FHA women, although both prolactin levels and FHA are associated with stress. Moreover, ...
Lire la suite >Purpose Functional hypothalamic amenorrhea (FHA) is due to hypothalamic dysregulation. Literature lacks data about prolactin in FHA women, although both prolactin levels and FHA are associated with stress. Moreover, polycystic ovarian morphology is common in FHA and there is an association between FHA and polycystic ovary syndrome. Thus, the aim of this study was to assess prolactin levels in FHA patients and controls with a special focus on factors influencing prolactin levels, that could be considered as “sensors” of the hypothalamic–pituitary dysregulation. Methods In a retrospective cohort study, 140 women with clearly defined FHA were compared to 70 healthy, normally ovulating women matched for age. The main outcome parameter was prolactin. Factors associated with prolactin levels > 12 µg/L were tested using a multivariable binary logistic regression model. Results The median prolactin level was 11.5 µg/L (interquartile range, IQR 7.5–14.4), which was similar to the control group (median 10.7, IQR 8.3–14.5; p = 0.065). Only two women had hyperprolactinemia (prolactin > 25 µg/L; 1.4%). In a multivariable binary logistic regression model eating disorder (odds ratio, OR 0.206; p = 0.040), excessive exercise (OR 0.280; p = 0.031) and TSH (OR 1.923; p = 0.020) were significantly associated with prolactin levels > 12 µg/L. Conclusion Women with FHA have similar prolactin levels to healthy age-matched individuals. Eating disorders and excessive exercise where associated with prolactin levels < 12 µg/L, in contrast to TSH.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-06-22T21:36:05Z
2024-07-08T12:52:07Z

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s00404-023-07277-1.pdf
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Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/115406*	2024-07-08T12:48:57Z
1	20.500.12210/115406.1	2024-06-22T21:36:05Z

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