Titre :

Stress and polycystic ovarian morphology in functional hypothalamic amenorrhea: a retrospective cohort study.

Auteur(s) :

Hager, M. [Auteur]
Dewailly, Didier [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Marculescu, R. [Auteur]
Ghobrial, S. [Auteur]
Parry, J. P. [Auteur]
Ott, J. [Auteur]

Titre de la revue :

Reproductive Biology and Endocrinology

Nom court de la revue :

Reprod Biol Endocrinol

Numéro :

21

Pagination :

42

Date de publication :

2023-05-13

ISSN :

1477-7827

Mot(s)-clé(s) en anglais :

Hypogonadotropic hypogonadism
Stress
Polycystic ovary syndrome

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Women with functional hypothalamic amenorrhea (FHA) reveal polycystic ovarian morphology (PCOM) in up to 50%. If stress sensitivity in women with polycystic ovary syndrome (PCOS) is the reason why PCOS women ...
Lire la suite >Background Women with functional hypothalamic amenorrhea (FHA) reveal polycystic ovarian morphology (PCOM) in up to 50%. If stress sensitivity in women with polycystic ovary syndrome (PCOS) is the reason why PCOS women are prone to develop FHA, patients with FHA caused by stress should reveal PCOM more often. Methods In a retrospective cohort study, 38 stress-associated and 38 excessive exercise-induced FHA women were included. The main outcome parameter was PCOM. In addition, the focus was on general patient characteristics as well as on prolactin, dehydroepiandrosterone-sulphate (DHEAS), and anti-Mullerian hormone (AMH). Results PCOM was found in 34/76 patients (44.7%). The stress group showed a higher prevalence of PCOM than the excessive exercise group (57.9% versus 31.6%, p = 0.019) as well as higher prolactin levels (median 13.2ng/mL versus 11.7ng/mL, p = 0.008) and a trend towards higher DHEAS levels (p = 0.058). Conclusions In FHA women, the PCOM prevalence was significantly higher in the stress-group than in the excessive exercise-group. The well-known stress sensitivity in women with PCOS might explain why PCOS women are prone to develop FHA as well as the high PCOM prevalence in FHA women.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-06-22T21:49:56Z
2024-07-08T08:26:08Z