Role of Anti-Müllerian Hormone in the Central Regulation of Fertility.

Cotellessa, Ludovica; Giacobini, Paolo

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1055/s-0044-1786050

PMID :

38608673

URL permanente :

http://hdl.handle.net/20.500.12210/115475

Titre :

Role of Anti-Müllerian Hormone in the Central Regulation of Fertility.

Auteur(s) :

Cotellessa, Ludovica [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Giacobini, Paolo [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

Seminars in Reproductive Medicine

Nom court de la revue :

Semin Reprod Med

Date de publication :

2024-04-19

ISSN :

1526-4564

Mot(s)-clé(s) en anglais :

AMH
hypothalamus
GnRH
PCOS
infertility

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

In recent years, the expanding roles of anti-Müllerian hormone (AMH) in various aspects of reproductive health have attracted significant attention. Initially recognized for its classical role in male sexual differentiation, ...
Lire la suite >In recent years, the expanding roles of anti-Müllerian hormone (AMH) in various aspects of reproductive health have attracted significant attention. Initially recognized for its classical role in male sexual differentiation, AMH is produced postnatally by the Sertoli cells in the male testes and by the granulosa cells in the female ovaries. Traditionally, it was believed to primarily influence gonadal development and function. However, research over the last decade has unveiled novel actions of AMH beyond the gonads, specifically all along the hypothalamic–pituitary–gonadal axis. This review will focus on the emerging roles of AMH within the hypothalamus and discusses its potential implications in reproductive physiology. Additionally, recent preclinical and clinical studies have suggested that elevated levels of AMH may disrupt the hypothalamic network regulating reproduction, which could contribute to the central pathophysiology of polycystic ovary syndrome. These findings underscore the intricate interplay between AMH and the neuroendocrine system, offering new avenues for understanding the mechanisms underlying fertility and reproductive disorders.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-06-24T21:05:54Z
2024-07-05T08:28:29Z

Numéro de version	Lien	Date de modification
2	20.500.12210/115475*	2024-07-05T08:26:47Z
1	20.500.12210/115475.1	2024-06-24T21:05:54Z

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