Titre :

Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity.

Auteur(s) :

Sanchez, C. [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Colson, C. [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Gautier, N. [Auteur]
Institut de Biologie Valrose [IBV]
Noser, P. [Auteur]
IT University of Copenhagen [ITU]
Salvi, J. [Auteur]
Université Bourgogne Franche-Comté [COMUE] [UBFC]
Villet, M. [Auteur]
Fleuriot, L. [Auteur]
Peltier, C. [Auteur]
Schlich, P. [Auteur]
Brau, F. [Auteur]
Sharif, Ariane [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Altintas, A. [Auteur]
Amri, E. Z. [Auteur]
Nahon, J. L. [Auteur]
Blondeau, N. [Auteur]
Benani, A. [Auteur]
Barrès, R. [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Rovère, C. [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]

Titre de la revue :

Brain Behav Immun

Nom court de la revue :

Brain Behav Immun

Numéro :

117

Pagination :

330-346

Éditeur :

Elsevier

Date de publication :

2024-03

ISSN :

1090-2139

Mot(s)-clé(s) en anglais :

Obesity
Neuroinflammation
High fat diet
Polyunsaturated fatty acids
ru6/ru3
Cognitive disorders
Anxiety
Memory
Hypothalamus
Hippocampus

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying ...
Lire la suite >Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-06-24T21:08:06Z
2024-12-04T10:52:58Z