Title :

Self-Immolative Polymers : A new way to depolymerize macromolecular architectures, leading to innovative drug delivery vectors

Author(s) :

Achour, Roukaya [Orateur]
Potier, Jonathan [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Belkhir, Kedafi [Auteur correspondant]
Unité Matériaux et Transformations (UMET) - UMR 8207

Conference title :

IUPAC MACRO 2024 THE 50TH WORLD POLYMER CONGRESS

City :

Warwick

Country :

Royaume-Uni

Start date of the conference :

2024-07-01

English abstract : [en]

Self-Immolative Polymers (SIPs) are stimuli-responsive macromolecules which undergo a fast cascade depolymerization reaction in response to the stimulus. This unique behavior allows the elaboration of temporary structures ...
Show more >Self-Immolative Polymers (SIPs) are stimuli-responsive macromolecules which undergo a fast cascade depolymerization reaction in response to the stimulus. This unique behavior allows the elaboration of temporary structures with high potential of use as drug delivery vectors. In this work, SIPs sensitive to both UV and NIR light have been developed. Amphiphilic macromolecular architectures were designed in order to ensure the formation of self-assemblies. The triggered depolymerization of the structures were monitored by different methods, proving the on-demand and controlled kinetics. These SIP-based structures are likely to overcome important barriers encountered in the field of drug delivery, such as the passive release of the drugs, and to provide On/Off release profilesShow less >

Language :

Anglais

Peer reviewed article :

Non

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2024-07-05T11:28:13Z