The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus

Debuysschere, Cyril; Nekoua, Magloire Pandoua; Alidjinou, Enagnon Kazali; Hober, Didier

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1038/s41574-024-01004-9

PMID :

38890459

URL permanente :

http://hdl.handle.net/20.500.12210/115943

Titre :

The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus

Auteur(s) :

Debuysschere, Cyril [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Nekoua, Magloire Pandoua [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Alidjinou, Enagnon Kazali [Auteur]

Laboratoire de virologie - ULR 3610
Hober, Didier [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]

Titre de la revue :

Nature Reviews Endocrinology

Nom court de la revue :

Nat Rev Endocrinol

Numéro :

Pagination :

588–599

Éditeur :

Nature Publishing Group

Date de publication :

2024-06-18

ISSN :

1759-5029

Mot(s)-clé(s) en anglais :

SARS-CoV-2
Type 1 diabetes

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Environmental factors, in particular viral infections, are thought to have an important role in the pathogenesis of type 1 diabetes mellitus (T1DM). The COVID-19 pandemic reinforced this hypothesis as many observational ...
Lire la suite >Environmental factors, in particular viral infections, are thought to have an important role in the pathogenesis of type 1 diabetes mellitus (T1DM). The COVID-19 pandemic reinforced this hypothesis as many observational studies and meta-analyses reported a notable increase in the incidence of T1DM following infection with SARS-CoV-2 as well as an association between SARS-CoV-2 infection and the risk of new-onset T1DM. Experimental evidence suggests that human β-cells express SARS-CoV-2 receptors and that SARS-CoV-2 can infect and replicate in β-cells, resulting in structural or functional alterations of these cells. These alterations include reduced numbers of insulin-secreting granules, impaired pro-insulin (or insulin) secretion, and β-cell transdifferentiation or dedifferentiation. The inflammatory environment induced by local or systemic SARS-CoV-2 infection might result in a set of signals (such as pro-inflammatory cytokines) that lead to β-cell alteration or apoptosis or to a bystander activation of T cells and disruption of peripheral tolerance that triggers autoimmunity. Other mechanisms, such as viral persistence, molecular mimicry and activation of endogenous human retroviruses, are also likely to be involved in the pathogenesis of T1DM following SARS-CoV-2 infection. This Review addresses the issue of the involvement of SARS-CoV-2 infection in the development of T1DM using evidence from epidemiological, clinical and experimental studies.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

Laboratoire de virologie - ULR 3610

Date de dépôt :

2024-07-12T21:01:08Z
2024-09-27T07:55:29Z

Numéro de version	Lien	Date de modification
2	20.500.12210/115943*	2024-09-27T07:49:59Z
1	20.500.12210/115943.1	2024-07-12T21:01:08Z

The relationship between SARS-CoV-2 infection ...

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The relationship between SARS-CoV-2 infection ... BibTeX CSV Excel RIS

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The relationship between SARS-CoV-2 infection ...

BibTeX

CSV

Excel

RIS