Titre :

Impact of primary endoscopic resection on oncological outcomes after esophagectomy for cancer: a retrospective propensity score-based cohort study

Auteur(s) :

Teixeira Farinha, Hugo [Auteur]
Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Behal, Helene [Auteur]
Service de Biostatistiques [CHRU Lille]
Cailliau, Emeline [Auteur]
Service de Biostatistiques [CHRU Lille]
Pasquer, Arnaud [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Duhamel, Alain [Auteur]
Service de Biostatistiques [CHRU Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Théréaux, Jérémie [Auteur]
Hôpital de la Cavale Blanche - CHRU Brest [CHU - BREST ]
Chalret Du Rieu, Mael [Auteur]
Clinique des cèdres - Ramsay Santé
Lefevre, Jérémie [Auteur]
CHU Saint-Antoine [AP-HP]
Turner, Kathleen [Auteur]
Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes]
Mantziari, Styliani [Auteur]
Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
Collet, Denis [Auteur]
Université de Bordeaux Ségalen [Bordeaux 2]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Piessen, Guillaume [Auteur]
Hôpital Claude Huriez [Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Gronnier, Caroline [Auteur]
Université de Bordeaux Ségalen [Bordeaux 2]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]

Titre de la revue :

Surgical Endoscopy

Nom court de la revue :

Surg Endosc

Numéro :

38

Pagination :

5169-5177

Éditeur :

Springer Verlag (Germany)

Date de publication :

2024-07-22

ISSN :

1432-2218

Mot(s)-clé(s) en anglais :

Endoscopic resection
Esophageal cancer
Esophagectomy
Oncological outcomes

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: Esophageal cancer posed significant global health challenges, particularly due to poor survival rates, especially in advanced stages. Primary endoscopic resection had emerged as an alternative treatment for ...
Lire la suite >Background: Esophageal cancer posed significant global health challenges, particularly due to poor survival rates, especially in advanced stages. Primary endoscopic resection had emerged as an alternative treatment for early esophageal cancer, aiming to preserve organ function and reduce surgical morbidity. Methods: This retrospective multicenter cohort study included 334 patients with early esophageal cancer (T1a-b, N0) from 30 French-speaking European centers between 2000 and 2010. Patients underwent either primary endoscopic resection followed by esophagectomy (E group, n = 36) or esophagectomy alone (S group, n = 298). Cox proportional hazards models adjusted for TNM stage and propensity score weighting were used to assess the impact of primary endoscopic resection on recurrence-free survival (RFS), overall survival (OS), and postoperative complications. Results: Primary endoscopic resection did not significantly influence RFS (adjusted HR 0.92, 95% CI 0.31 to 2.68, p = 0.88) or OS (adjusted HR 1.06, 95% CI 0.35 to 3.13, p = 0.92) compared to esophagectomy alone. Initial higher thromboembolic complications in the endoscopic resection group were not significant after adjustment (adjusted OR 4.73, 95% CI 0.34 to 64.27, p = 0.24). Conclusions: Primary endoscopic resection followed by esophagectomy for early esophageal cancer did not alter oncological outcomes or overall survival in this retrospective cohort. These findings supported the role of primary endoscopic resection as a safe initial treatment strategy, warranting validation in larger prospective studies. Registration: Our study was registered retrospectively on the Clinicaltrials.com website under the identifier NCT01927016. We acknowledge the importance of prospective registration and regret that this was not done before the commencement of the study.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2024-10-17T21:04:35Z
2024-10-31T15:00:11Z