Titre :

Mixed Features and Nonfatal Suicide Attempt Among Individuals With Major Depressive Episode: Insights From the French MHGP Survey.

Auteur(s) :

Peyre, H. [Auteur]
Université Paris-Saclay
CHU Montpellier = Montpellier University Hospital
Hoertel, N. [Auteur]
Hôpital Corentin Celton [Issy-les-Moulineaux]
Université Paris Cité [UPCité]
Pignon, B. [Auteur]
Université Paris-Est Créteil Val-de-Marne - Faculté de médecine [UPEC Médecine]
Amad, Ali [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Roelandt, J. L. [Auteur]
Etablissement Public de Santé Mentale de Lille-Métropole [Armentières] [EPSM]
Benradia, I. [Auteur]
Etablissement Public de Santé Mentale de Lille-Métropole [Armentières] [EPSM]
Thomas, Pierre [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Vaiva, Guillaume [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Geoffroy, P. A. [Auteur]
Institut de médecine et d'épidémiologie appliquée [AP-HP Hôpital Bichat-Claude Bernard] [IMEA]
Olié, E. [Auteur]
Fondation FondaMental [Créteil]
Université de Montpellier [UM]
Courtet, P. [Auteur]
Université de Montpellier [UM]
Fondation FondaMental [Créteil]

Titre de la revue :

J Clin Psychiatry

Nom court de la revue :

J Clin Psychiatry

Numéro :

85

Date de publication :

2024-11-18

ISSN :

1555-2101

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: This study explores among individuals with a major depressive episode (MDE) the potential impact of mixed features on the risk of suicide attempt, suicidal thoughts, self-harm intentions, and thoughts of ...
Lire la suite >Background: This study explores among individuals with a major depressive episode (MDE) the potential impact of mixed features on the risk of suicide attempt, suicidal thoughts, self-harm intentions, and thoughts of death. Methods: Data from the French Mental Health in General Population (MHGP) survey (1999-2003) were analyzed, including 128 participants meeting DSM 5 criteria for MDE with mixed features (MDE with at least 3 manic symptoms) and 3,312 participants experiencing MDE without mixed features. Our primary analysis focused on suicide attempt, with additional examination of recent suicidal thoughts, self-harm intentions, and thoughts of death. Multivariable regression models were performed to adjust for potential confounding variables, including sociodemographics, previous suicide attempt, number of depressive symptoms, and psychiatric comorbidity. Results: MDE with mixed features was significantly associated with an increased risk of suicide attempt (adjusted odds ratio [AOR] = 1.69; 95% CI, 1.26-2.25). This association did not significantly differ between men and women. Furthermore, the number of manic symptoms demonstrated a dose-dependent relationship with an increased risk of suicide attempt (AOR = 1.18; 95% CI, 1.07-1.30; P < .001). Mixed features were also associated with suicide attempt among individuals with MDE and without recent suicidal thoughts (AOR = 2.74; 95% CI, 1.36-5.54). Conclusion: This study underscores the importance of assessing mixed features when evaluating the risk of suicide attempt in individuals with MDE. Mechanisms underlying this association might be independent of progression from thoughts of death to suicidal thoughts, suicidal intention, and ultimately, suicide attempt.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-12-03T22:01:13Z
2025-03-05T12:20:10Z