Titre :

Optimization of the formulation of an original hydrogel-based bone cement using a mixture design

Auteur(s) :

Ly, Océane [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Monchau, Francine [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Rémond, Sébastien [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]
Lors, Christine [Auteur]
Centre for Materials and Processes [CERI MP - IMT Nord Europe]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]
Jouanneaux, Alain [Auteur]
Institut des Molécules et Matériaux du Mans [IMMM]
Debarre, Étienne [Auteur]
Université d'Artois [UA]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Damidot, Denis [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]

Titre de la revue :

Journal of the Mechanical Behavior of Biomedical Materials

Pagination :

103886

Éditeur :

Elsevier

Date de publication :

2020-10

ISSN :

1751-6161

Mot(s)-clé(s) en anglais :

Mixture design
Bone cement
2-hydroxyethyl methacrylate
Optimization
Mechanical properties
Rheology
Swelling

Discipline(s) HAL :

Chimie/Matériaux
Chimie/Chimie organique
Chimie/Polymères
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Biotechnologies
Sciences du Vivant [q-bio]/Ingénierie biomédicale
Sciences de l'ingénieur [physics]/Mécanique [physics.med-ph]/Mécanique des matériaux [physics.class-ph]
Statistiques [stat]/Méthodologie [stat.ME]

Résumé en anglais : [en]

Highly swelling polymers, i.e. superabsorbent hydrogels, are hydrophilic, three dimensional networks that can easily absorb a significant amount water, fluid or drug. They are widely used in various applications such as ...
Lire la suite >Highly swelling polymers, i.e. superabsorbent hydrogels, are hydrophilic, three dimensional networks that can easily absorb a significant amount water, fluid or drug. They are widely used in various applications such as foods, cosmetics, and medical devices. Bone cements are used in orthopaedics as a filling biomaterial or as a grout enhancing the embedding of a prosthesis into bone and fixation is achieved by mechanical interlock with metal or bone surfaces. Recently, hydrophilic bone cements have attracted the attention for bone tissue-engineering applications. Here a bone cement containing an acrylic hydrogel (HEMA) as a liquid phase and a blend of corn starch, cellulose acetate and bioceramic filler as a solid phase is investigated by means of a mixture design which is a special topic within statistical Design of Experiments (DoE). Output variables of interest, complex shear modulus, compressive modulus and swelling rate related to rheological, mechanical and swelling properties respectively, are measured for each cement formulation. Applying the mixture design strategy enables to assess the impact of the three powder components on each variable of interest and to determine the optimal formulation in order to achieve the required properties of this HEMA-based bone cement, especially the rheology adapted to the desired clinical application, but also appropriate mechanical and swelling properties.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515

Source :

Harvested from HAL

Date de dépôt :

2025-02-26T10:20:59Z