Title :

Tristetraprolin Family Members and Processing Bodies: A Complex Regulatory Network Involved in Fatty Liver Disease, Viral Hepatitis and Hepatocellular Carcinoma.

Author(s) :

Gellée, Noémie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Legrand, Noemie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Jouve, Mickael [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Devaux, Pierre-Jean [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dubuquoy, Laurent [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sobolewski, Cyril [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Journal title :

Cancers (Basel)

Abbreviated title :

Cancers (Basel)

Volume number :

17

Pages :

348

Publisher :

MDPI

Publication date :

2025-02-16

ISSN :

2072-6694

English keyword(s) :

tristetraprolin
MASLD
hepatocellular carcinoma
viral hepatitis
alcohol-related liver disease
processing bodies

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Chronic liver diseases, such as those encountered with obesity, chronic/abusive alcohol consumption or viral infections, represent not only major public health concerns with limited therapeutic options but also important ...
Show more >Chronic liver diseases, such as those encountered with obesity, chronic/abusive alcohol consumption or viral infections, represent not only major public health concerns with limited therapeutic options but also important risk factors for the onset of hepatocellular carcinoma (HCC). Deciphering the molecular traits underlying these disorders is of high interest for designing new and effective treatments. The tristetraprolin (TTP) family members are of particular importance given their ability to control the expression of a wide range of genes involved in metabolism, inflammation and carcinogenesis at the post-transcriptional level. This regulation can occur within small cytoplasmic granules, namely, processing bodies (P-bodies), where the mRNA degradation occurs. Increasing evidence indicates that TTP family members and P-bodies are involved in the development of chronic liver diseases and cancers. In this review, we discuss the role of this regulatory mechanism in metabolic-dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), hepatic viral infections and HCC.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2025-02-26T22:00:30Z
2025-03-19T07:10:25Z