Clinical Impact of Antifungal Susceptibility, ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Candida Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort
Auteur(s) :
Gangneux, Jean-Pierre [Auteur]
Institut de recherche en santé, environnement et travail [Irset]
Cornet, Muriel [Auteur]
Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 [TIMC-IMAG]
Bailly, Sebastien [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Fradin, Chantal [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Feger, Celine [Auteur]
Timsit, Jean-Francois [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Leroy, Olivier [Auteur]
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Bougnoux, Marie-Elisabeth [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Institut de recherche en santé, environnement et travail [Irset]
Cornet, Muriel [Auteur]
Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 [TIMC-IMAG]
Bailly, Sebastien [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Fradin, Chantal [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Feger, Celine [Auteur]
Timsit, Jean-Francois [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Leroy, Olivier [Auteur]
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Bougnoux, Marie-Elisabeth [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Titre de la revue :
Frontiers in Microbiology
Nom court de la revue :
Front. Microbiol.
Numéro :
9
Date de publication :
2018-12-11
ISSN :
1664-302X
Mot(s)-clé(s) en anglais :
Candida albicans
Candida glabrata
virulence
biofilm
mannoglycoconjugates
oligomannosides
in vitro sensitivity
invasive candidiasis
Candida glabrata
virulence
biofilm
mannoglycoconjugates
oligomannosides
in vitro sensitivity
invasive candidiasis
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background: The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown.
Methods: Candida strains isolated during the AmarCAND2 study were centrally analyzed ...
Lire la suite >Background: The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown. Methods: Candida strains isolated during the AmarCAND2 study were centrally analyzed for species identification, antifungal susceptibility, biofilm formation, and expression of surface and glycoconjugate mannosides. Correlation between these phenotypical features and patient outcome was sought using a multivariable Cox survival model. Results: Candida albicans was predominant (65.4%, n = 285), with a mortality rate significantly lower than that in patients with non-albicans strains [HR 0.67 (0.46–1.00), p = 0.048]. The rate of fluconazole-resistant strains was low (C. albicans and Candida glabrata: 3.5 and 6.2%, respectively) as well as caspofungin-resistant ones (1 and 3.1%, respectively). Early biofilm formation was less frequent among C. albicans (45.4%) than among non-albicans (81.2%). While the strains of C. albicans showed variable levels of surface mannosides expression, strains isolated from candidemia exhibited a high expression of β-man, which was correlated with an increased mortality (p = 0.02). Conclusion: Candida albicans IC were associated with lower mortality, and with strains that exhibited less frequently early biofilm formation than non-albicans strains. A high expression of β-man was associated with increased IC mortality. Further studies are warranted to confirm this data and to evaluate other virulence factors in yeasts.Lire moins >
Lire la suite >Background: The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown. Methods: Candida strains isolated during the AmarCAND2 study were centrally analyzed for species identification, antifungal susceptibility, biofilm formation, and expression of surface and glycoconjugate mannosides. Correlation between these phenotypical features and patient outcome was sought using a multivariable Cox survival model. Results: Candida albicans was predominant (65.4%, n = 285), with a mortality rate significantly lower than that in patients with non-albicans strains [HR 0.67 (0.46–1.00), p = 0.048]. The rate of fluconazole-resistant strains was low (C. albicans and Candida glabrata: 3.5 and 6.2%, respectively) as well as caspofungin-resistant ones (1 and 3.1%, respectively). Early biofilm formation was less frequent among C. albicans (45.4%) than among non-albicans (81.2%). While the strains of C. albicans showed variable levels of surface mannosides expression, strains isolated from candidemia exhibited a high expression of β-man, which was correlated with an increased mortality (p = 0.02). Conclusion: Candida albicans IC were associated with lower mortality, and with strains that exhibited less frequently early biofilm formation than non-albicans strains. A high expression of β-man was associated with increased IC mortality. Further studies are warranted to confirm this data and to evaluate other virulence factors in yeasts.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2019-10-22T08:16:27Z
2023-12-06T15:18:33Z
2023-12-06T15:18:33Z
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- fmicb-09-02907.pdf
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