Guidance on harmonised methodologies for ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals
Auteur(s) :
More, Simon John [Auteur]
Hardy, Anthony [Auteur]
Bampidis, Vasileios [Auteur]
Benford, Diane [Auteur]
Hougaard-Bennekou, Susanne [Auteur]
Bragard, Claude [Auteur]
Boesten, Jos [Auteur]
Halldorsson, Thorhallur Ingi [Auteur]
Hernandez-Jerez, Antonio F. [Auteur]
Jeger, Michael John [Auteur]
Knutsen, Helle Katrine [Auteur]
Koutsoumanis, Konstantinos Panagiotis [Auteur]
Naegeli, Hanspeter [Auteur]
Noteborn, Hubert [Auteur]
Ockleford, Colin [Auteur]
Ricci, Antonia [Auteur]
Rychen, Guido [Auteur]
Schlatter, Josef Rudolf [Auteur]
Silano, Vittorio [Auteur]
Nielsen, Soren Saxmose [Auteur]
Schrenk, Dieter [Auteur]
Solecki, Roland [Auteur]
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Younes, Maged [Auteur]
Benfenati, Emilio [Auteur]
Castle, Laurence [Auteur]
Cedergreen, Nina [Auteur]
Laskowski, Ryszard [Auteur]
Leblanc, Jean Charles [Auteur]
Kortenkamp, Andreas [Auteur]
Ragas, Ad [Auteur]
Posthuma, Leo [Auteur]
Svendsen, Claus [Auteur]
Testai, Emanuela [Auteur]
Dujardin, Bruno [Auteur]
Kass, George E. N. [Auteur]
Manini, Paola [Auteur]
Jeddi, Maryam Zare [Auteur]
Dorne Jean, Lou C. M. [Auteur]
Hogstrand, Christer [Auteur]
Hardy, Anthony [Auteur]
Bampidis, Vasileios [Auteur]
Benford, Diane [Auteur]
Hougaard-Bennekou, Susanne [Auteur]
Bragard, Claude [Auteur]
Boesten, Jos [Auteur]
Halldorsson, Thorhallur Ingi [Auteur]
Hernandez-Jerez, Antonio F. [Auteur]
Jeger, Michael John [Auteur]
Knutsen, Helle Katrine [Auteur]
Koutsoumanis, Konstantinos Panagiotis [Auteur]
Naegeli, Hanspeter [Auteur]
Noteborn, Hubert [Auteur]
Ockleford, Colin [Auteur]
Ricci, Antonia [Auteur]
Rychen, Guido [Auteur]
Schlatter, Josef Rudolf [Auteur]
Silano, Vittorio [Auteur]
Nielsen, Soren Saxmose [Auteur]
Schrenk, Dieter [Auteur]
Solecki, Roland [Auteur]
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Younes, Maged [Auteur]
Benfenati, Emilio [Auteur]
Castle, Laurence [Auteur]
Cedergreen, Nina [Auteur]
Laskowski, Ryszard [Auteur]
Leblanc, Jean Charles [Auteur]
Kortenkamp, Andreas [Auteur]
Ragas, Ad [Auteur]
Posthuma, Leo [Auteur]
Svendsen, Claus [Auteur]
Testai, Emanuela [Auteur]
Dujardin, Bruno [Auteur]
Kass, George E. N. [Auteur]
Manini, Paola [Auteur]
Jeddi, Maryam Zare [Auteur]
Dorne Jean, Lou C. M. [Auteur]
Hogstrand, Christer [Auteur]
Titre de la revue :
EFSA Journal
Nom court de la revue :
EFSA J.
Numéro :
17
Date de publication :
2019-03-01
ISSN :
1831-4732
Mot(s)-clé(s) en anglais :
dose addition
mixtures
harmonised methodologies
risk assessment
combined exposure to multiple chemicals
interactions
response addition
mixtures
harmonised methodologies
risk assessment
combined exposure to multiple chemicals
interactions
response addition
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, ...
Lire la suite >This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology is given, including existing frameworks for these risk assessments. This background was evaluated, resulting in a harmonised framework for risk assessment of combined exposure to multiple chemicals. The framework is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterisation, and risk characterisation including uncertainty analysis), with tiered and stepwise approaches for both whole mixture approaches and component-based approaches. Specific considerations are given to component-based approaches including the grouping of chemicals into common assessment groups, the use of dose addition as a default assumption, approaches to integrate evidence of interactions and the refinement of assessment groups. Case studies are annexed in this guidance document to explore the feasibility and spectrum of applications of the proposed methods and approaches for human and animal health and ecological risk assessment. The Scientific Committee considers that this Guidance is fit for purpose for risk assessments of combined exposure to multiple chemicals and should be applied in all relevant areas of EFSA's work. Future work and research are recommended.Lire moins >
Lire la suite >This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology is given, including existing frameworks for these risk assessments. This background was evaluated, resulting in a harmonised framework for risk assessment of combined exposure to multiple chemicals. The framework is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterisation, and risk characterisation including uncertainty analysis), with tiered and stepwise approaches for both whole mixture approaches and component-based approaches. Specific considerations are given to component-based approaches including the grouping of chemicals into common assessment groups, the use of dose addition as a default assumption, approaches to integrate evidence of interactions and the refinement of assessment groups. Case studies are annexed in this guidance document to explore the feasibility and spectrum of applications of the proposed methods and approaches for human and animal health and ecological risk assessment. The Scientific Committee considers that this Guidance is fit for purpose for risk assessments of combined exposure to multiple chemicals and should be applied in all relevant areas of EFSA's work. Future work and research are recommended.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2019-10-22T08:16:58Z
2023-12-01T17:41:50Z
2023-12-01T17:49:17Z
2023-12-01T17:52:32Z
2023-12-01T17:41:50Z
2023-12-01T17:49:17Z
2023-12-01T17:52:32Z
Fichiers
- EFSA Journal - 2019 - - Guidance on harmonised methodologies for human health animal health and ecological risk.pdf
- Non spécifié
- Accès libre
- Accéder au document