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Role of cerebral microbleeds for intracerebral ...
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Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
10.1007/s11910-019-0969-0
PMID :
31218453
Permalink :
http://hdl.handle.net/20.500.12210/15842
Title :
Role of cerebral microbleeds for intracerebral haemorrhage and dementia
Author(s) :
Moulin, Solene [Auteur]
Cordonnier, Charlotte [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Journal title :
Current Neurology and Neuroscience Reports
Abbreviated title :
Curr Neurol Neurosci Rep
Volume number :
19
Pages :
51
Publication date :
2019-06-19
ISSN :
1534-6293
English keyword(s) :
Ischaemic stroke
Cerebral microbleeds
Cognitive impairment
Dementia
Intracerebral haemorrhage
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: Cerebral microbleeds (CMB)-small round or ovoid lesions detected in hyposignal on blood-sensitive MRI sequences-are promising radiological biomarkers of cerebral small vessel disease. Their relations with ischaemic ...
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OBJECTIVE: Cerebral microbleeds (CMB)-small round or ovoid lesions detected in hyposignal on blood-sensitive MRI sequences-are promising radiological biomarkers of cerebral small vessel disease. Their relations with ischaemic or haemorragic stroke and their potential contribution to dementia have been extensively addressed. This article reviews recent research on the clinical significance of CMB that remains to be determined. RESULTS: The presence, burden and location of CMB allow to obtain a more accurate estimate of intracerebral haemorrhage and ischaemic stroke risk. Most studies evaluating the association between CMB and dementia are hampered by methodological limitations and show conflicting results. CMB mainly reflect the severity of the underlying small vessel disease and should not be interpreted independently of the others neuroimaging biomarkers or the clinical setting. Future large prospective longitudinal studies and randomized controlled trials in various settings are required to determine whether specific therapies are beneficial in case of incidental findings.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Collections :
  • Lille Neurosciences & Cognition (LilNCog) - U 1172
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T13:01:42Z
Université de Lille

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