Bioavailable trace metals in neurological diseases

Poujois, Aurelia; Devedjian, Jean-Christophe; moreau, caroline; DEVOS, DAVID; Chaine, Pascal; Woimant, France; Duce, James A.

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1007/s11940-016-0426-1

PMID :

27682263

Permalink :

http://hdl.handle.net/20.500.12210/16074

Title :

Bioavailable trace metals in neurological diseases

Author(s) :

Poujois, Aurelia [Auteur]
Devedjian, Jean-Christophe [Auteur]
moreau, caroline [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
DEVOS, DAVID [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Chaine, Pascal [Auteur]
Woimant, France [Auteur]
Duce, James A. [Auteur]

Journal title :

Current treatment options in neurology

Abbreviated title :

Curr. Treat. Options Neurol.

Volume number :

Publication date :

2016-10-01

ISSN :

1092-8480

English keyword(s) :

Iron
Copper
Neurodegeneration
Reactive species
Chelation therapy
Manganese

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first ...
Show more >Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first being a de-coppering phase and the second a maintenance one. The best therapeutic approach remains controversial, as only a few non-controlled trials have compared these treatments. During the initial phase, progressive increase of chelators' doses adjusted to exchangeable copper and urinary copper might help to avoid neurological deterioration. Liver transplantation is indicated in acute fulminant liver failure and decompensated cirrhosis; in cases of neurologic deterioration, it must be individually discussed. During the maintenance phase, the most important challenge is to obtain a good adherence to lifelong medical therapy. Neurodegenerative diseases that lead to a mislocalisation of iron can be caused by a culmination of localised overload (pro-oxidant siderosis) and localised deficiency (metabolic distress). A new therapeutic concept with conservative iron chelation rescues iron-overloaded neurons by scavenging labile iron and, by delivering this chelated metal to endogenous apo-transferrin, allows iron redistribution to avoid systemic loss of iron.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:05:03Z

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