Titre :

The dose-effect relationship of baclofen in alcohol dependence: a 1-year cohort study

Auteur(s) :

Pignon, Baptiste [Auteur]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Auffret, Marine [Auteur]
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Deheul, Sylvie [Auteur]
Simioni, Nicolas [Auteur]
Cottencin, Olivier [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Rolland, Benjamin [Auteur]

Titre de la revue :

Human psychopharmacology

Nom court de la revue :

Hum Psychopharmacol

Numéro :

32

Date de publication :

2017-07-01

ISSN :

1099-1077

Mot(s)-clé(s) en anglais :

dose-effect relationship
alcoholism
baclofen
drug effect
off-label
treatment outcome
Mesh:Middle Aged
Mesh:Proportional Hazards Models
Mesh:Treatment Outcome
Mesh:Alcoholism/drug therapy*
Mesh:Alcohol Drinking
Mesh:Alcohol Deterrents/administration & dosage*
Mesh:Adult
Mesh:Baclofen/administration & dosage*
Mesh:Dose-Response Relationship
Mesh:Drug
Mesh:Female
Mesh:Follow-Up Studies
Mesh:Humans
Mesh:Male

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Sciences cognitives

Résumé en anglais : [en]

Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence. Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed ...
Lire la suite >Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence. Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year. For each patient-month of treatment, the maximum daily dose of baclofen (DDB) and average weekly alcohol consumption (AWAC) were calculated. We defined a favorable drinking outcome as an AWAC under 200 g/w for at least 2 consecutive months. We divided the DDB of each patient-month into 3 categories (low dose: <90 mg/d, medium dose: 90-150 mg/d, and high dose: >150 mg/d) and investigated the relationship between reaching a favorable outcome and the concurrent DDB category in a time-varying Cox regression analysis. Hazard ratios (HRs) were adjusted based on age, sex, and initial AWAC. One hundred forty subjects were followed during at least 1 month. Of these patients, 58 (41%) had a favorable drinking outcome. In comparison to low dose, medium dose was associated with a decreased rate of favorable drinking outcome (HR = 0.42; 95% CI [0.20, 0.88]), whereas no difference was found with high dose (HR = 1.31; 95% CI [0.65, 2.64]). The relationship between dose of baclofen and favorable drinking outcome was U-shaped, that is, was increased at low and high doses compared to medium doses.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T13:35:50Z
2020-01-21T15:37:36Z