Titre :

Daphne: a new tool for the assessment of the behavioral variant of frontotemporal dementia

Auteur(s) :

Boutoleau-Bretonniere, Claire [Auteur]
Evrard, Christelle [Auteur]
Hardouin, Jean Benoit [Auteur]
Rocher, Laetitia [Auteur]
Charriau, Tiphaine [Auteur]
Etcharry-Bouyx, Frederique [Auteur]
Auriacombe, Sophie [Auteur]
Richard-Mornas, Aurelie [Auteur]
Lebert, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Sauvaget, Anne [Auteur]
Bulteau, Samuel [Auteur]
Vercelletto, Martine [Auteur]
Derkinderen, Pascal [Auteur]
Bretonniere, Cedric [Auteur]
Thomas-Anterion, Catherine [Auteur]

Titre de la revue :

Dementia and Geriatric Cognitive Disorders Extra

Nom court de la revue :

Dement Geriatr Cogn Dis Extra

Numéro :

5

Pagination :

503-16

Date de publication :

2015-01-01

ISSN :

1664-5464

Mot(s)-clé(s) en anglais :

Progressive supranuclear palsy
Alzheimer''s disease
Behavioral disorders
Frontotemporal dementia
Scale
Bipolar disorder

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, ...
Lire la suite >BACKGROUND: The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, justifying development of new clinical tools. OBJECTIVE: We produced a behavioral inventory named DAPHNE. This scale (adapted from Rascovsky's criteria) explores six domains: disinhibition, apathy, perseverations, hyperorality, personal neglect and loss of empathy. It is composed of ten items (five answer categories). The aim was (1) to assess the validity and reliability of DAPHNE and (2) to evaluate its contribution in differentiating patients. METHODS: Two scores were computed: DAPHNE-6 (screening) from the six domains and DAPHNE-40 (diagnosis) from the ten items. Reliability and reproducibility were assessed. External validity was studied with the Frontal Behavioral Inventory (FBI) and the Frontotemporal Behavioral Scale (FBS). Finally, the diagnostic performance of DAPHNE was compared to revised criteria, FBI and FBS. RESULTS: DAPHNE was administered to the caregivers of 89 patients, 36 with bvFTD, 22 with Alzheimer's disease, 15 with progressive supranuclear palsy and 16 with bipolar disorder. Reliability and reproducibility were excellent, as was external validity. DAPHNE-6 allowed bvFTD diagnosis (score ≥4) with a sensitivity of 92%, while DAPHNE-40 (score ≥15) had a specificity of 92%. CONCLUSIONS: We demonstrate excellent psychometric features for DAPHNE. This quick tool could help for both diagnosing and screening bvFTD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T14:28:45Z