Imaging spectrum of Bing–Neel syndrome: ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Imaging spectrum of Bing–Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström’s macroglobulinemia?
Author(s) :
Fitsiori, Aikaterini [Auteur]
Fornecker, Luc-Matthieu [Auteur]
Simon, Laurence [Auteur]
Karentzos, Alexandros [Auteur]
Galanaud, Damien [Auteur]
Outteryck, Olivier [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Vermersch, Patrick [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Pruvo, Jean-Pierre [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Gerardin, Emmanuel [Auteur]
Lebrun-Frenay, Christine [Auteur]
Lafitte, François [Auteur]
Cottier, Jean-Philippe [Auteur]
Clerc, Christine [Auteur]
De Seze, Jerome [Auteur]
Dietemann, Jean-Louis [Auteur]
Kremer, Stéphane [Auteur]
Fornecker, Luc-Matthieu [Auteur]
Simon, Laurence [Auteur]
Karentzos, Alexandros [Auteur]
Galanaud, Damien [Auteur]
Outteryck, Olivier [Auteur]

Lille Inflammation Research International Center (LIRIC) - U995
Vermersch, Patrick [Auteur]

Lille Inflammation Research International Center (LIRIC) - U995
Pruvo, Jean-Pierre [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Gerardin, Emmanuel [Auteur]
Lebrun-Frenay, Christine [Auteur]
Lafitte, François [Auteur]
Cottier, Jean-Philippe [Auteur]
Clerc, Christine [Auteur]
De Seze, Jerome [Auteur]
Dietemann, Jean-Louis [Auteur]
Kremer, Stéphane [Auteur]
Journal title :
European Radiology
Abbreviated title :
Eur Radiol
Volume number :
29
Pages :
102-114
Publication date :
2019-01
ISSN :
1432-1084
English keyword(s) :
Magnetic resonance imaging
Lymphocytes
Meninges
Central nervous system
Lymphocytes
Meninges
Central nervous system
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: Bing-Neel syndrome (BNS) is a rare neurological complication of Waldenström's macroglobulinemia. The aim of this study is to describe the spectrum of radiological manifestations of this syndrome and their ...
Show more >OBJECTIVE: Bing-Neel syndrome (BNS) is a rare neurological complication of Waldenström's macroglobulinemia. The aim of this study is to describe the spectrum of radiological manifestations of this syndrome and their prevalence in order to facilitate its early diagnosis. METHODS: Twenty-four patients with BNS were diagnosed between 1994 and 2016 in eight centres in France. We retrospectively examined the medical records of these patients as well as the corresponding literature, focusing on imaging studies. Recorded data were statistically analysed and radiological findings described. RESULTS: The mean age of our patients was 62.4 years (35-80 years). The vast majority of patients were men, with a male to female ratio of 9:1. Findings included parenchymal or meningeal involvement or both. The most common finding was leptomeningeal infiltration, either intracranial or spinal, with a prevalence reaching 70.8%. Dural involvement was present in 37.5% of patients. In 41.7% (10/24) of patients, there was parenchymal involvement with a higher prevalence of brain comparing to medullar involvement (33.3% and 23.1% respectively). High T2 signal of the parenchyma was identified in 41.7% of patients and high signal in diffusion was evident in 25% of them. Intraorbital or periorbital involvement was also detected in four cases. A proposition regarding the appropriate imaging protocol completed our study. CONCLUSIONS: BNS's diagnosis remains challenging. Central nervous system MRI findings in the setting of known or suspected Waldenström's macroglobulinemia appear to be highly suggestive of BNS and appropriate imaging protocols should be implemented for their depiction. CONCLUSIONS: • Diagnosis of Bing-Neel syndrome (BNS) remains challenging and recent expert recommendations include MRI in the diagnostic criteria for the syndrome. • The most common radiological manifestations of BNS are leptomeningeal/dural infiltration or parenchymal involvement of brain or spinal cord, but many atypical forms may exist with various presentations. • Appropriate imaging protocol for BNS should include enhanced MRI studies of both brain and spine.Show less >
Show more >OBJECTIVE: Bing-Neel syndrome (BNS) is a rare neurological complication of Waldenström's macroglobulinemia. The aim of this study is to describe the spectrum of radiological manifestations of this syndrome and their prevalence in order to facilitate its early diagnosis. METHODS: Twenty-four patients with BNS were diagnosed between 1994 and 2016 in eight centres in France. We retrospectively examined the medical records of these patients as well as the corresponding literature, focusing on imaging studies. Recorded data were statistically analysed and radiological findings described. RESULTS: The mean age of our patients was 62.4 years (35-80 years). The vast majority of patients were men, with a male to female ratio of 9:1. Findings included parenchymal or meningeal involvement or both. The most common finding was leptomeningeal infiltration, either intracranial or spinal, with a prevalence reaching 70.8%. Dural involvement was present in 37.5% of patients. In 41.7% (10/24) of patients, there was parenchymal involvement with a higher prevalence of brain comparing to medullar involvement (33.3% and 23.1% respectively). High T2 signal of the parenchyma was identified in 41.7% of patients and high signal in diffusion was evident in 25% of them. Intraorbital or periorbital involvement was also detected in four cases. A proposition regarding the appropriate imaging protocol completed our study. CONCLUSIONS: BNS's diagnosis remains challenging. Central nervous system MRI findings in the setting of known or suspected Waldenström's macroglobulinemia appear to be highly suggestive of BNS and appropriate imaging protocols should be implemented for their depiction. CONCLUSIONS: • Diagnosis of Bing-Neel syndrome (BNS) remains challenging and recent expert recommendations include MRI in the diagnostic criteria for the syndrome. • The most common radiological manifestations of BNS are leptomeningeal/dural infiltration or parenchymal involvement of brain or spinal cord, but many atypical forms may exist with various presentations. • Appropriate imaging protocol for BNS should include enhanced MRI studies of both brain and spine.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T14:28:56Z
2023-12-08T12:47:12Z
2023-12-13T09:47:18Z
2023-12-08T12:47:12Z
2023-12-13T09:47:18Z