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Microbiologic profile of staphylococci ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1089/sur.2013.258
PMID :
25650692
Permalink :
http://hdl.handle.net/20.500.12210/16926
Title :
Microbiologic profile of staphylococci isolated from osteoarticular infections: evolution over ten years
Author(s) :
Titecat, Marie [Auteur] refId
Lille Inflammation Research International Center - U 995 [LIRIC]
Senneville, Eric [Auteur] refId
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Wallet, Frederic [Auteur] refId
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dezeque, Herve [Auteur]
Migaud, Henri [Auteur] refId
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Courcol, Rene J. [Auteur]
Loiez, Caroline [Auteur]
Journal title :
Surgical infections
Abbreviated title :
Surg. Infect.
Volume number :
16
Pages :
77-83
Publication date :
2015-02-01
ISSN :
1096-2964
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Staphylococci, especially coagulase-negative staphylococci (CoNS) represent the most frequent micro-organism associated with osteoarticular infections (OAIs), especially those involving orthopedic devices. The ...
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BACKGROUND: Staphylococci, especially coagulase-negative staphylococci (CoNS) represent the most frequent micro-organism associated with osteoarticular infections (OAIs), especially those involving orthopedic devices. The antibiotic susceptibility profile of the bacteria mostly responsible for OAIs is therefore crucial information for choosing the appropriate antibiotic regimen administered during the removal procedure until the first results of the conventional culture. METHODS: The antibiotic susceptibility profile of staphylococci isolated from OAIs in a referent center for osteoarticular infection was studied over a 10-y period to adapt antibiotic protocols to the ecology. RESULTS: From 2002 to 2011, the resistance of Staphylococcus aureus to methicillin and rifampicin decreased (27.9% versus 20.6% and 13% versus 1%, respectively); the resistance to fluoroquinolones (FQ) was stable (24% on average), and all the isolates were susceptible to glycopeptides. For CoNS, the resistance to methicillin, rifampicin, and FQ increased (30.4% versus 43.9%, 13% versus 18.5%, and 20.3% versus 34.1%, respectively) over the same period. Resistance of the CoNS to vancomycin was observed in 2011 for the first time (2.3%), and 3.8% were resistant to teicoplanin in 2002 compared with 22% in 2011, with 3.5% resistant to linezolid in 2011. CONCLUSIONS: The sensibility of bacteria over 10 y remained stable, except for CoNS. The increase of the resistances for CoNS led us to exclude teicoplanin from the first-line empiric antibiotic treatment, to avoid linezolid, and to prefer vancomycin or daptomycin.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Univ. Littoral Côte d’Opale
Université de Lille
Collections :
  • Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
  • Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
  • METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Submission date :
2019-12-09T16:51:25Z
Université de Lille

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