Titre :

Retrospective study of imported falciparum malaria in french paediatric intensive care units

Auteur(s) :

Lanneaux, Justine [Auteur]
Dauger, Stéphane [Auteur]
Pham, Luu-Ly [Auteur]
Naudin, Jerome [Auteur]
Faye, Albert [Auteur]
Gillet, Yves [Auteur]
Bosdure, Emmanuelle [Auteur]
Carbajal, Ricardo [Auteur]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Vialet, Renaud [Auteur]
Cheron, Gerard [Auteur]
Angoulvant, François [Auteur]

Titre de la revue :

Archives of disease in childhood

Nom court de la revue :

Arch. Dis. Child.

Numéro :

101

Pagination :

1004-1009

Date de publication :

2016-11-01

ISSN :

0003-9888

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: The World Health Organization (WHO) severity criteria for paediatric Plasmodium falciparum METHODS: Retrospective case-control study. METHODS: Eight French university hospitals, from 2006 to 2012. METHODS: ...
Lire la suite >OBJECTIVE: The World Health Organization (WHO) severity criteria for paediatric Plasmodium falciparum METHODS: Retrospective case-control study. METHODS: Eight French university hospitals, from 2006 to 2012. METHODS: Children with Pf malaria admitted to paediatric intensive care units (cases: n=55) or paediatric emergency departments (controls: n=110). METHODS: Descriptive analysis of WHO severity criteria and major interventions (mechanical ventilation, blood transfusion, fluid challenge, treatment of cerebral oedema, renal replacement therapy). Thresholds were set by receiver operating characteristics curve analysis. RESULTS: Altered consciousness (71% vs 5%), shock (24% vs 1%), renal failure (20% vs 1%), anaemia <50 g/L (7% vs 2%), acidosis (38% vs 0%), bilirubin level >50 µmol/L (25% vs 8%) and parasitaemia >10% (30% vs 8%) were more frequent in cases (p<0.01). All these criteria were associated with major interventions (p<0.001). Respiratory distress (six cases), and hypoglycaemia (two cases) were infrequent. Thrombocytopenia <50 000/mm3 CONCLUSIONS: The WHO severity criteria for paediatric Pf malaria are relevant for countries without endemic malaria. The infrequent but severe complications also provide a timely reminder of the morbidity and mortality associated with this condition worldwide. In non-endemic countries haemoglobin <70 g/L and platelet count <50 000/mm3Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T16:53:47Z