Routine drug resistance testing in proviral ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Routine drug resistance testing in proviral hiv-1 dna: prevalence of stop codons and hypermutation, and associated factors
Author(s) :
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Deldalle, Josephine [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Robineau, Olivier [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Hallaert, Christophe [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Meybeck, Agnes [Auteur]
Centre Hospitalier Tourcoing
Huleux, Thomas [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Ajana, Faiza [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Hober, Didier [Auteur]
215293|||Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie] (VALID)
Pathogenèse virale du diabète de type 1 - ULR 3610
Bocket, Laurence [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
![refId](/themes/Mirage2//images/idref.png)
Laboratoire de virologie - ULR 3610
Deldalle, Josephine [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Robineau, Olivier [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Hallaert, Christophe [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Meybeck, Agnes [Auteur]
Centre Hospitalier Tourcoing
Huleux, Thomas [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Ajana, Faiza [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Hober, Didier [Auteur]
![refId](/themes/Mirage2//images/idref.png)
215293|||Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie] (VALID)
Pathogenèse virale du diabète de type 1 - ULR 3610
Bocket, Laurence [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Journal title :
Journal of medical virology
Abbreviated title :
J. Med. Virol.
Volume number :
91
Pages :
1684-1687
Publication date :
2019-03-30
ISSN :
1096-9071
English keyword(s) :
hypermutation
drug resistance
HIV-1 DNA
stop codons
sequencing
mutations
drug resistance
HIV-1 DNA
stop codons
sequencing
mutations
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was ...
Show more >We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was identified in 6.2% of HIV-1 DNA sequences, among which 54.8% were hypermutated. The defective virus group (SC w/o HM) was similar to the non-SC group regarding the characteristics of HIV-1 infection, and before drug exposure. In addition, the HIV-1 DNA levels were not different between both groups. Sequences with SC/HM displayed a higher proportion of RAMs. The impact of the SC/HM associated RAMs on clinical responses requires further investigation.Show less >
Show more >We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was identified in 6.2% of HIV-1 DNA sequences, among which 54.8% were hypermutated. The defective virus group (SC w/o HM) was similar to the non-SC group regarding the characteristics of HIV-1 infection, and before drug exposure. In addition, the HIV-1 DNA levels were not different between both groups. Sequences with SC/HM displayed a higher proportion of RAMs. The impact of the SC/HM associated RAMs on clinical responses requires further investigation.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Collections :
Submission date :
2019-12-09T16:54:41Z
2024-02-23T09:07:47Z
2024-02-23T09:07:47Z