Titre :

Competing risk of death and end-stage renal disease in incident chronic kidney disease (stages 3 to 5): the epiran community-based study

Auteur(s) :

Ayav, Carole [Auteur]
BEUSCART, Jean-Baptiste [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Briancon, Serge [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Frimat, Luc [Auteur]
Kessler, Michele [Auteur]

Titre de la revue :

BMC nephrology

Nom court de la revue :

BMC Nephrol.

Numéro :

17

Date de publication :

2016-11-15

ISSN :

1471-2369

Mot(s)-clé(s) en anglais :

Risk factors
Epidemiological study
Incidence
Chronic kidney disease
Competing-risk analysis
Outcomes
Mesh:Prospective Studies
Mesh:Renal Dialysis/mortality
Mesh:Kidney Failure
Mesh:Chronic/therapy
Mesh:Male
Mesh:Renal Dialysis/trends
Mesh:Residence Characteristics*
Mesh:Risk Factors
Mesh:Kidney Failure
Mesh:Chronic/mortality*
Mesh:Kidney Failure
Mesh:Chronic/diagnosis*
Mesh:Incidence
Mesh:Humans
Mesh:France/epidemiology
Mesh:Follow-Up Studies
Mesh:Female
Mesh:Cohort Studies
Mesh:Adult
Mesh:Aged
Mesh:Aged
Mesh:80 and over
Mesh:Middle Aged
Mesh:Mortality/trends

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed. From ...
Lire la suite >Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed. From a community-based sample of 4,409 individuals residing in a well-defined geographical area, we determined the number of patients having a first serum creatinine value ≥1.7 mg/dL and present for at least 3 months that allowed us to calculate an annual incidence rate of CKD (stages 3 to 5). CKD (stages 3 to 5) was defined by estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 A total of 631 incident CKD patients (stages 3 to 5) were followed-up until the occurrence of death and dialysis initiation for more than 3 years. The annual incidence rate of CKD (stages 3 to 5) was estimated at 977.7 per million inhabitants. Analyses were performed on 514 patients with available medical data. During the study, 155 patients (30.2 %) were referred to a nephrologist, 193 (37.5 %) died and 58 (11.3 %) reached end-stage renal disease and initiated dialysis. A total of 139 patients (27.6 %) had a fast decline of their renal function, 92 (18.3 %) a moderate decline and the 272 remaining patients had a physiological decline (21.1 %) or a small improvement of their renal function (33.0 %). Predictors of death found in both Cox and Fine-Gray multivariable regression models included age at diagnosis, anemia, active neoplasia and chronic heart failure, but not a low glomerular filtration rate (GFR). Age at diagnosis, anemia and a low GFR were independently associated with dialysis initiation in Cox model, but anemia was not found to be a risk factor for dialysis initiation in Fine-Gray model. This large cohort study provided useful epidemiological data on incident CKD (stages 3 to 5) and stressed the need to improve the hands-on implementation of clinical practice guidelines for the evaluation and the management of CKD in primary care.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T18:15:31Z