Title :

Reappraisal of eligibility criteria in cancer clinical trials

Author(s) :

Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Lebellec, Loic [Auteur]
Université de Lille
Vanseymortier, Marie [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]

Journal title :

Current opinion in oncology

Abbreviated title :

Curr Opin Oncol

Volume number :

30

Pages :

352-357

Publisher :

Wolters Kluwer

Publication date :

2018-07-16

ISSN :

1531-703X

English keyword(s) :

cancer clinical trials
generalizability
phase trials
eligibility criteria
participant protection

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. There is an intrinsic tension between two opposite ...
Show more >We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. There is an intrinsic tension between two opposite purposes when it comes to defining eligibility criteria: on the one hand, participants must be protected, and on the other, the study population must be defined as accurately as possible. However, stringent eligibility criteria jeopardize the feasibility of trials, and, consequently, the generalizability of trial results. Therefore, interdisciplinary working groups under the auspices of the American Society of Clinical Oncology and Friends of Cancer Research propose to adapt/relax some of the classical eligibility criteria. In-depth reflection of the existing eligibility criteria, and implementation of recent recommendations are needed.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:19:01Z
2024-03-06T11:11:51Z