Dermatofibrosarcoma: management
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Dermatofibrosarcoma: management
Auteur(s) :
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
El Bedoui, Sophie [Auteur]
Robin, Yves-Marie [Auteur]
Decanter, Gauthier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
El Bedoui, Sophie [Auteur]
Robin, Yves-Marie [Auteur]
Decanter, Gauthier [Auteur]
Titre de la revue :
Bulletin du cancer
Nom court de la revue :
Bull Cancer
Date de publication :
2018-10-05
ISSN :
1769-6917
Mot(s)-clé(s) en anglais :
Imatinib
Dermatofibrosarcoma
Fusion gene
Mohs microsurgery
Margins
Dermatofibrosarcoma
Fusion gene
Mohs microsurgery
Margins
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific ...
Lire la suite >Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). The risk of metastatic relapse is low (and related to fibrosarcoma component); the risk of local relapse depends on the quality of surgery. Management of localized DFSP is based on large resection with meticulous analysis of margins (with or without Mohs microsurgery). Advanced stages not amenable to surgery or metastatic DFSP (with presence of COL1A1;PDGFB) are best treated with imatinib. Locally advanced DFSP potentially amenable to curative intent surgery could be treated with imatinib as neo-adjuvant treatment. The management of these tumours requires multidisciplinary expertise.Lire moins >
Lire la suite >Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). The risk of metastatic relapse is low (and related to fibrosarcoma component); the risk of local relapse depends on the quality of surgery. Management of localized DFSP is based on large resection with meticulous analysis of margins (with or without Mohs microsurgery). Advanced stages not amenable to surgery or metastatic DFSP (with presence of COL1A1;PDGFB) are best treated with imatinib. Locally advanced DFSP potentially amenable to curative intent surgery could be treated with imatinib as neo-adjuvant treatment. The management of these tumours requires multidisciplinary expertise.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Université de Lille
Université de Lille
Date de dépôt :
2019-12-09T18:19:30Z